Depression Clinical Trials

Showing 2641-2660 of 3,654 trials

Effects of Noninvasive Brain Stimulation Techniques on BDNF Levels

NCT02652832

The aim of this study is to investigate the effects of non invasive brain stimulation - NIBS - techniques (Electroconvulsivotherapy - ECT, transcranial Direct Current Stimulation - tDCS, repetitive transcranial magnetic stimulation - rTMS) on serum Brain Derived Neurotrophic factor (BDNF) levels in patients with depression and schizophrenia. Four blood samples will be collected in each participants, one before the NIBS sessions, and 3 after the completion of NIBS protocols: one immediately after the end of the NIBS sessions, a second one week after and a last one month after. Two blood samples separated by one month will also be collected in a a group of healthy volunteers.

DepressionSchizophrenia

Hôpital le Vinatier200 participantsStarted Dec 2010

Bron, France

COMPLETEDNA

Canadian rTMS Treatment and Biomarker Network in Depression Trial

NCT02729792

Repetitive transcranial magnetic stimulation (rTMS) is an emerging treatment for medically refractory major depressive disorder (MDD). rTMS involves direct stimulation of cortical neurons using externally applied, powerful, focused magnetic field pulses. Dozens of studies and several meta-analyses over the last 15 years have shown that rTMS of the dorsolateral prefrontal cortex (DLPFC) produces statistically significant improvements in MDD, even when medications have failed. However, other possible targets may also yield improvement in symptoms. In an attempt to enhance the therapeutic efficacy of current interventions for TRD, attention has turned to identifying domain-specific biomarkers in hopes of ultimately individualizing and predicting treatment response. Unfortunately, the precise nature of this relationship is less than clear, as reflected by the fact that even now there are no established biomarkers that are used routinely in clinical practice to aid in diagnosis. This study also seeks to examine a comprehensive suite of biomarker measurements (MRI, neurophysiology, and genomics/proteomics) before and after rTMS treatment.

Depression

Centre for Addiction and Mental Health212 participantsStarted Mar 2016

Vancouver, British Columbia, Canada • Toronto, Ontario, Canada • Toronto, Ontario, Canada

Effects of Noninvasive Brain Stimulation Techniques on BDNF Levels

Canadian rTMS Treatment and Biomarker Network in Depression Trial

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