Clinical Trials in Boston

Showing 12741-12760 of 15,299 trials

Fluoxetine for Motor, Aphasia, and Neglect Recovery After Ischemic Stroke

NCT01674868

This pilot study will recruit 25 subjects to assess the feasibility of replicating the FLAME study (Chollet, et al. Lancet 2011), a randomized controlled trial (RCT) that assessed the effect of fluoxetine vs placebo on motor recovery after ischemic stroke, in an American sample of post-acute stroke patients. This trial will in addition examine the effect of treatment with fluoxetine versus placebo on concurrent deficits in language and hemispatial attention, as well as post-stroke fatigue and will evaluate the durability of observed effects. The results of this pilot trial will be used to develop power estimates for a larger trial and to evaluate recruitment and intervention completion rates for subjects in an American post-acute environment. There are two additional substudies: the first will use MRI to assess structural changes at the beginning and end of the intervention; the second will examine the relationship of serum biomarkers of inflammation to the intervention.

Stroke

Spaulding Rehabilitation HospitalStarted Apr 2013

Boston, Massachusetts, United States

COMPLETEDPhase 2< 1 mile

Efficacy and Safety of Squalamine Lactate Eye Drops in Subjects With Neovascular (Wet) Age-related Macular Degeneration (AMD)

NCT01678963

The purpose of this study is to evaluate the safety and efficacy of topical ophthalmic squalamine lactate eye drops in treating patients with neovascular age-related macular degeneration (wet AMD), a degenerative retinal eye disease that causes a progressive, irreversible, severe loss of central vision.

Neovascular Age Related Macular Degeneration

Ohr Pharmaceutical Inc.142 participantsStarted Nov 2012

Tucson, Arizona, United States • Bakersfield, California, United States • Beverly Hilss, California, United States +17 more locations

Fluoxetine for Motor, Aphasia, and Neglect Recovery After Ischemic Stroke

Efficacy and Safety of Squalamine Lactate Eye Drops in Subjects With Neovascular (Wet) Age-related Macular Degeneration (AMD)

Find Trials by Condition in Boston

Phase 3 Study of EBI-005 in Dry Eye Disease

Efficacy of a 12-Week Regimen of Telaprevir, Pegylated Interferon, and Ribavirin in Treatment-Naive and Prior Relapser Subjects With Interleukin28B (IL28B) CC Genotype

Red Cell Storage Duration Study

Treatment for Subjects With Unresectable Stage III or Stage IV Melanoma

Airway Epithelium Gene Expression: AEGIS IDE

Study of EBI-005 in Dry Eye Disease (DED)

Prevention of Seasonal Affective Disorder

An Open Label Study of the Effect of Telaprevir in Combination With Ribavirin and Peginterferon on HCV Infection in Stable Liver Transplant Patients

Treating Schizophrenic Smokers: Effects on Craving, Cues and Withdrawal

Growth Observational Study

Early Surfactant to Reduce Use of Mechanical Breathing in Low Birth Weight Infants

Safety Trial of Naproxen Sodium/ Diphenhydramine

Open-Label Assessment of the Albuterol Spiromax® Dry Powder Inhaler (DPI)

A Randomized Trial of Unruptured Brain AVMs

Barusiban Subcutaneously for Reducing Implantation Failure Due to Uterine Contractions

Study To Compare On-Demand Treatment To A Prophylaxis Regimen Of BeneFIX In Subjects With Moderately Severe to Severe Hemophilia B

Efficacy of Exenatide Once Weekly and Once-Daily Insulin Glargine in Patients With Type 2 Diabetes Treated With Metformin Alone or in Combination With Sulfonylurea (DURATION - 3)

ALLPS VERSUS PVO Randomized Controlled Trial