ALLPS VERSUS PVO Randomized Controlled Trial

Inclusion Criteria

• •Patient must have extensive liver tumors that would require portal vein embolization or a two-stage hepatectomy and portal vein embolization or ligation by the judgment of surgeons in the tumor board.
• •Patient may have extrahepatic disease as long as it may be addressed after liver surgery and there is a tumor board decision to proceed with liver resection (mostly applicable to CRC metastases).
• •Patient may have received previous chemotherapy.
• •In cases of cholestasis, preoperative drainage procedures (PTC or ERCP) are left up to judgement of physicians.
• •Patient must be = 18 years of age. The patient population over 65 years old needs to be carefully included based on comorbidities.
• •Patient may have undergone previous liver resection.
• •Patient's location must be such that proper staging and follow-up may be performed.
• •Patient's case must be presented at the Multidisciplinary Meeting attended by hepatobiliary surgeons, oncologists, hepatologists, and radiologists, or must be approved directly by Dr. Strasberg or Dr. Chapman.