Depression Clinical Trials

Showing 41-60 of 3,090 trials

PD, PK, and Safety of ALTO-203 in Patients With MDD

NCT06391593

The goal of this clinical trial is to determine the pharmacodynamic effects of ALTO-203 in patients with MDD in a randomized, placebo-controlled, single-dose crossover treatment period. Additionally, safety, tolerability, and PK will be assessed in a subsequent randomized placebo-controlled multi-dose parallel-group treatment period of 28 days. Participants will complete subjective response questionnaires and perform cognitive tasks during the single-dose period, in which participants will receive ALTO-203 25 μg and 75 μg, as well as placebo. During the multiple-dose period, participants will receive either ALTO-203 25 μg, 75 μg , or placebo. Safety will be assessed over the single dose and 28-day multiple dose periods.

Major Depressive DisorderAnhedonia

Alto Neuroscience69 participantsStarted Mar 2024

Tucson, Arizona, United States • Oceanside, California, United States • Torrance, California, United States +12 more locations

RECRUITINGPhase 2

TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors

NCT06801041

This clinical research study is to learn about the feasibility, safety, and effects of psilocybin-assisted psychotherapy for cancer survivors with depression and/or anxiety.

DepressionAnxietyCancer

M.D. Anderson Cancer Center20 participantsStarted May 2025

Houston, Texas, United States

PD, PK, and Safety of ALTO-203 in Patients With MDD

TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors

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