Clinical Study of Escitalopram Oxalate Combined With taVNS in Depression and Concomitant Inflammatory Symptoms

Exclusion Criteria

• •Brain organic lesions (such as cerebral hemorrhage, large area cerebral infarction, encephalitis, epilepsy); cardiac QTc interval \> 450ms;
• •Currently or have been diagnosed with other major diseases (such as coronary heart disease, pulmonary heart disease, etc.)
• •Those who are currently or have been diagnosed with other mental disorders other than major depressive disorder (except for anxiety disorder);
• •Patients who have a serious risk of suicide or who have had suicide attempts;
• •Those who are using or have been treated with escitalopram oxalate are not effective;
• •Those who are participating in or have participated in vagus nerve or transcranial electrical stimulation for less than 3 months;
• •MRI scan taboos and high-risk groups;
• •Pregnancy, breastfeeding or planning for pregnancy during the trial;
• •Refusal to sign informed consent.