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Browse 3,654 clinical trials for depression. Find studies that match your criteria and connect with research centers.
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NCT07316647
This study aims to test whether a brief digital intervention using conversational AI can improve mental health outcomes among school-aged youth (grades 6-8) in India, where most young people with mental health issues do not receive treatment. The intervention teaches "growth mindset", the belief that skills and abilities can improve with effort, via a 45-minute interactive conversation with an AI chatbot (spread across two class periods). A randomized controlled trial with approximately 430 students at a private, English-medium school in Bangalore will evaluate whether interacting with the chatbot can reduce symptoms of anxiety and depression while enhancing growth mindset beliefs. Half the students will receive the full intervention at baseline, while the other half (control group) will complete a usual school assignment; after 7 weeks, the control group will receive a shortened (15-minute) version of the growth mindset intervention. Participants will complete 10-minute surveys at baseline, 3 weeks, and 7 weeks, after which all students will receive a printed booklet with all the information from the chatbot. This study represents one of the first randomized controlled trials evaluating conversational AI as a brief digital intervention for youth mental health.
NCT04332146
Postnatal psychopathology have adverse impact on both mothers and infants. Few postnatal women with depressive symptoms receive treatment, and pharmacological intervention has not been well accepted due to the medication side-effects. Recently, mindfulness-based interventions were found to be beneficial for symptoms in perinatal and antenatal women with depression. These non-pharmacological interventions require less resources and are more feasible for postnatal women to practice at home. To date, no randomized controlled trial has examined mindfulness-based intervention program as a treatment for women with postnatal depression. The proposed randomized controlled trial aims to examine the effects of an 8-week mindfulness-based intervention program on symptom and cognition for postnatal females with depressive symptoms. A total of 70 postnatal women with depressive symptoms will be recruited from the psychiatric outpatient clinics in Hong Kong, and will be randomized into two groups: 1) an 8-week mindfulness-based intervention program (n=35); 2) a booklet-based psychoeducation control group (n=35). All participants will be assessed for depression, anxiety, stress, cognition, role functioning, quality of life, sleep quality and mindfulness ability at the baseline, 8 weeks, and 3 months after intervention. The intervention sessions will be held once weekly lasting 90 minutes for 8 weeks. The investigators primarily hypothesize that participants in the mindfulness-based intervention group will improve depressive symptom after 8 weeks compared with the control group. Secondary, the mindfulness-based intervention will improve anxiety, stress, cognitive functions, sleep quality, quality of life and mindfulness ability.