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Clareo Health | Depression Clinical Trials in Philadelphia | 174 Studies

Clinical Trials DepressionPhiladelphia

Depression Clinical Trials in Philadelphia

Find 174 clinical trials for depression near Philadelphia, Pennsylvania. Connect with research centers in your area.

All Depression trials nationwide All trials in Philadelphia

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RecruitingNot yet recruitingActive, not recruitingEnrolling by invitationCompletedTerminated

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Early phase 1Phase 1Phase 1–2Phase 2Phase 2–3Phase 3Phase 4No phase

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Showing 61-80 of 174 trials

CompletedAdaptive Design Study of NEST sTMS in Subjects With Major Depressive DisorderThis is a double-blind, sham controlled, multi-center study to confirm the safety and efficacy of synchronized transcranial magnetic stimulation (sTMS) for the treatment of…NCT03288714·La Jolla, California and 13 others CompletedBehavioral Activation and Varenicline for Smoking Cessation in Depressed SmokersPersons who struggle with depression smoke at high rates and experience low quit rates in treatment.NCT02378714·Chicago, Illinois and 1 other CompletedA Study to Evaluate Sleep Electroencephalogram (EEG) Features (Brain Activity While Sleeping) in Participants With Major Depressive Disorder (MDD)The purpose of this study is to evaluate sleep in participants with Major Depressive Disorder with moderate to severe insomnia symptoms (MDDIS) or MDD with no or mild insomnia…NCT07258485·Phoenix, Arizona and 22 others

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Data from ClinicalTrials.govTerms

CompletedA Study to Evaluate the Efficacy and Safety of Fremanezumab for Preventive Treatment of Migraine in Patients With Major Depressive DisorderThe primary objective is to evaluate the efficacy of monthly 225 mg sc fremanezumab in adult participants with migraine and major depressive disorder (MDD) The secondary…NCT04041284·Little Rock, Arkansas and 63 others

RecruitingA Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)This Phase 2 study (protocol number VLS-01-203) will determine the efficacy, safety, and tolerability of short-term treatment with a VLS-01 transmucosal buccal film (VLS-01-BU) in…NCT06524830·Tucson, Arizona and 47 others

CompletedEfficacy and Safety Study of a Combination Product [Drug:BCI-024 (Buspirone) and Drug:BCI-049 (Melatonin)] to Treat Major Depressive Disorder (MDD)The primary objective of this study are to evaluate the synergistic effect of a combination product, consisting of drug BCI-024 (buspirone) and drug BCI-049 (melatonin), in…NCT00705003·Garden Grove, California and 8 others

CompletedThe Effectiveness of rTMS in Depressed VA PatientsThe purpose of this multi-site trial is to determine if repetitive Transcranial Magnetic Stimulation (rTMS) helps people with depression who have not been helped by medications or…NCT01191333·Palo Alto, California and 8 others

TerminatedSPD489 Adult Major Depressive Disorder (MDD) Open-label Safety and Tolerability Rollover Extension StudyThis study is an optional continuation of previous short-term adult major depressive disorder (MDD) augmentation studies.NCT01436175·Birmingham, Alabama and 211 others

CompletedStudy of the Safety and Efficacy of Fixed-dose Brexpiprazole (OPC-34712) as Adjunctive Therapy in the Treatment of Adults With Major Depressive Disorder With and Without Anxious DistressThe purpose of this study is to assess the tolerability, safety, and efficacy of brexpiprazole (2.0 mg/day) as adjunctive therapy in adult subjects with a diagnosis of MDD with…NCT02196506·Birmingham, Alabama and 46 others

CompletedA Study of Aticaprant as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant TherapyThe purpose of this study is to evaluate the efficacy of aticaprant compared with placebo as adjunctive therapy to an antidepressant in improving depressive symptoms in adult…NCT05455684·Tucson, Arizona and 119 others

CompletedA Study of ALKS 5461 for the Treatment of Major Depressive Disorder (MDD) - the FORWARD-4 StudyThis study will evaluate the efficacy and safety of ALKS 5461.NCT02158533·Birmingham, Alabama and 48 others

CompletedA Study Comparing the Efficacy and Safety of Duloxetine and Placebo for the Treatment of Depression in Elderly PatientsThe purpose of this study is to compare the efficacy and safety of duloxetine 60 mg once daily to placebo on depression in elderly patients (greater than or equal to 65 years of…NCT00406848·Pasadena, California and 32 others

TerminatedStudy to Assess the Safety and Effectiveness of NMRA-335140-501This is a 52-week open-label extension (OLE) study that will evaluate the safety, tolerability, and effectiveness of NMRA-335140 in participants with major depressive disorder…NCT06029439·Huntsville, Alabama and 177 others

CompletedA Study of Aripiprazole in Patients With Major Depressive DisorderThe purpose of this 14 week, randomized, double-blind, placebo controlled study is to assess the safety and efficacy of aripiprazole to placebo as adjunctive treatment to an…NCT00105196·Birmingham, Alabama and 33 others

TerminatedOpen-label Long Term (52 Weeks) Safety and Tolerability of Agomelatine Sublingual Tablets in Major Depressive Disorder (MDD)The study will assess safety and tolerability of 0.5 mg/day and 1 mg/day of sublingual (under the tongue) formulation of agomelatine (AGO178) in patients with Major Depressive…NCT01156415·Birmingham, Alabama and 97 others

CompletedStudy Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) vs. Escitalopram in Postmenopausal WomenDesvenlafaxine succinate (DVS) is a potent and selective serotonin and norepinephrine reuptake inhibitor (SNRI).NCT00406640·Peoria, Arizona and 69 others

Enrolling by invitationAn Open-Label Study of Azetukalner in Major Depressive DisorderX-NOVA-OLE is a multicenter, open-label study to evaluate the long-term safety, tolerability, and efficacy of azetukalner as a monotherapy in adult participants who successfully…NCT06922110·Phoenix, Arizona and 70 others

CompletedVortioxetine, 5, 10, and 20 mg, Relapse Prevention Study in Adults With Major Depressive Disorder (MDD)The purpose of this study is to evaluate the efficacy of vortioxetine (5, 10, and 20 mg) versus placebo during the first 28 weeks of the 32-week double-blind treatment period in…NCT02371980·Phoenix, Arizona and 78 others

CompletedStudy of the Safety and Efficacy of OPC-34712 as Adjunctive Therapy in the Treatment of Adults With Major Depressive DisorderThis is a Double-blind study wherein patients with Major Depressive Disorder (MDD) will receive either from 1 to 3 mg a day of study medication (OPC-34712)or placebo (an inactive…NCT01052077·Birmingham, Alabama and 42 others

TerminatedRandomized, Double-Blind, Placebo-Controlled Trial of REL-1017 as Adjunctive Treatment for MDDA Phase 3, randomized, double-blind, placebo-controlled, multicenter trial of REL-1017 in patients with major depressive disorder (MDD).NCT06011577·Dothan, Alabama and 35 others

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