Depression Clinical Trials

Showing 1-20 of 3,479 trials

Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar Disorder

NCT05837104

This is a randomized, double-blind, placebo-controlled proof-of-concept clinical trial to assess the efficacy and safety of Magnesium-vitamin B6in combination with treatment as usual for treating symptoms of depression, stress, and anxiety in patients with first episode bipolar I disorder.

Bipolar I DisorderDepression, AnxietyStress

Mclean Hospital40 participantsStarted Dec 2023

Belmont, Massachusetts, United States

Not Yet RecruitingNA

Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms

NCT07610928

Many Asian Americans with depression also struggle with physical symptoms-such as pain, fatigue, or other forms of bodily discomfort-that occur at the same time. Right now, there is no proven treatment that effectively addresses both the depression and these physical symptoms together. This study will test whether it is practical, acceptable, and safe to combine the Stress Management and Resiliency Training (SMART) program with meditative movements for people who have both major depression and these distressing physical symptoms.

Depression / Major Depressive DisorderMental Health (Depression)

Massachusetts General Hospital70 participantsStarted Jun 2026

RECRUITINGPhase 3

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

NCT07592689

A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating DT120 Compared to Placebo in Major Depressive Disorder - Ascend

Major Depressive Disorder

Definium Therapeutics US, Inc.165 participantsStarted May 2026

Gilbert, Arizona, United States • Little Rock, Arkansas, United States • San Diego, California, United States +24 more locations

Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar Disorder

Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms

A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

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