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Clareo Health | Depression Clinical Trials in Houston | 165 Studies

Clinical Trials DepressionHouston

Depression Clinical Trials in Houston

Find 165 clinical trials for depression near Houston, Texas. Connect with research centers in your area.

All Depression trials nationwide All trials in Houston

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RecruitingNot yet recruitingActive, not recruitingEnrolling by invitationCompletedTerminated

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Early phase 1Phase 1Phase 1–2Phase 2Phase 2–3Phase 3Phase 4No phase

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Showing 61-80 of 165 trials

CompletedEfficacy and Safety Study of a Combination Product [Drug:BCI-024 (Buspirone) and Drug:BCI-049 (Melatonin)] to Treat Major Depressive Disorder (MDD)The primary objective of this study are to evaluate the synergistic effect of a combination product, consisting of drug BCI-024 (buspirone) and drug BCI-049 (melatonin), in…NCT00705003·Garden Grove, California and 8 others CompletedLong-term Safety Study of Rapastinel as Adjunctive Therapy in Patients With Major Depressive DisorderThis study will evaluate the long-term safety and tolerability of rapastinel as an adjunctive to antidepressant therapy (ADT) in patients with major depressive disorder (MDD).NCT03002077·Birmingham, Alabama and 127 others

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Data from ClinicalTrials.govTerms

TerminatedThe UTHealth Ketamine ProjectThe primary objective of this study is to determine the effectiveness of serial infusions of intravenous (IV) ketamine in adults with treatment resistant depression (TRD).NCT02882711·Houston, Texas

CompletedELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)The goal of the study is to conduct a comparative randomized trial of electroconvulsive therapy (ECT) vs. ketamine for patients with treatment resistant depression (TRD) in a real…NCT03113968·New Haven, Connecticut and 4 others

CompletedA Study of Adjunctive Aripiprazole in Participants With Major Depressive DisorderThis trial is a 14 week, randomized, double-blind, placebo controlled study, to assess the safety and efficacy of aripiprazole as adjunctive treatment to an ongoing antidepressant…NCT00095758·Beverly Hills, California and 27 others

CompletedSPD489 in Adults With Persistent Executive Function Impairments (EFI) and Partial or Full Remission of Recurrent Major Depressive DisorderTo evaluate the efficacy of SPD489 for the treatment of executive function impairments (EFI) when used as an adjunct to stable, standard therapy in the setting of partial or full…NCT00985725·Imperial, California and 32 others

TerminatedSPD489 Adult Major Depressive Disorder (MDD) Open-label Safety and Tolerability Rollover Extension StudyThis study is an optional continuation of previous short-term adult major depressive disorder (MDD) augmentation studies.NCT01436175·Birmingham, Alabama and 211 others

RecruitingGamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant DepressionThe core objective of this study is to enhance the translational potential of this electroencephalogram (EEG) biomarker by using ketamine(KET)-induced gamma potentiation as a…NCT06480201·Houston, Texas and 1 other

RecruitingEvaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive DisorderThe purpose of this study is to determine the efficacy and safety of milsaperidone compared to placebo as adjunctive therapy in patients with Major Depressive DisorderNCT06830044·Phoenix, Arizona and 52 others

CompletedA Study of Aticaprant as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant TherapyThe purpose of this study is to evaluate the efficacy of aticaprant compared with placebo as adjunctive therapy to an antidepressant in improving depressive symptoms in adult…NCT05455684·Tucson, Arizona and 119 others

CompletedA Study of ALKS 5461 for the Treatment of Major Depressive Disorder (MDD) - the FORWARD-4 StudyThis study will evaluate the efficacy and safety of ALKS 5461.NCT02158533·Birmingham, Alabama and 48 others

Enrolling by invitationCortical rTMS as a Treatment for DepressionMajor depressive disorder (MDD) is a leading cause of disability worldwide with a 19% lifetime prevalence in the United States.NCT05487911·Houston, Texas

CompletedLong-term Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy in Patients With Major Depressive DisorderThe objective of this study is to evaluate the long-term safety and tolerability of cariprazine as an adjunctive treatment to antidepressant therapy (ADT) in patients with Major…NCT01838876·Tucson, Arizona and 89 others

CompletedA Study of Rapastinel as Adjunctive Therapy in the Prevention of Relapse in Patients With Major Depressive DisorderThis study will evaluate the efficacy, safety and tolerability of rapastinel 450 milligrams (mg) intravenous (IV) once weekly or once every 2 weeks versus placebo as an adjunctive…NCT02951988·Birmingham, Alabama and 136 others

TerminatedStudy to Assess the Safety and Effectiveness of NMRA-335140-501This is a 52-week open-label extension (OLE) study that will evaluate the safety, tolerability, and effectiveness of NMRA-335140 in participants with major depressive disorder…NCT06029439·Huntsville, Alabama and 177 others

CompletedCombination Deplin® and Antidepressant Therapy for a Major Depressive Episode (MDE)- a Retrospective AnalysisThis is a retrospective chart review study to determine if Deplin® 7.5mg-15mg combined with an antidepressant is better than an antidepressant alone in adults with major…NCT01001559·Houston, Texas

TerminatedOpen-label Long Term (52 Weeks) Safety and Tolerability of Agomelatine Sublingual Tablets in Major Depressive Disorder (MDD)The study will assess safety and tolerability of 0.5 mg/day and 1 mg/day of sublingual (under the tongue) formulation of agomelatine (AGO178) in patients with Major Depressive…NCT01156415·Birmingham, Alabama and 97 others

CompletedA Study to Compare the Efficacy, Safety, and Tolerability of JNJ-42847922 Versus Quetiapine Extended-Release as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant TherapyThe purpose of this study is to assess the efficacy of flexibly dosed JNJ-42847922 (20 milligram \[mg\] or 40 mg) compared to flexibly dosed quetiapine extended-release (XR) (150…NCT03321526·Phoenix, Arizona and 49 others

CompletedStudy Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) vs. Escitalopram in Postmenopausal WomenDesvenlafaxine succinate (DVS) is a potent and selective serotonin and norepinephrine reuptake inhibitor (SNRI).NCT00406640·Peoria, Arizona and 69 others

CompletedVortioxetine, 5, 10, and 20 mg, Relapse Prevention Study in Adults With Major Depressive Disorder (MDD)The purpose of this study is to evaluate the efficacy of vortioxetine (5, 10, and 20 mg) versus placebo during the first 28 weeks of the 32-week double-blind treatment period in…NCT02371980·Phoenix, Arizona and 78 others

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