Effect of Systemic Inflammation on Emotion and Cognition in Patients With Mood Disorder - A Vaccine Study

Exclusion Criteria

• •Volunteers who received this vaccine within 3 years or any other vaccine within 3 months
• •Patients with existing inflammatory conditions (connective tissue disorder, autoimmune conditions, neoplastic disease, chronic infections, etc.)
• •Patients with acute viral or bacterial infection
• •Hospitalized patients
• •Patients in acute phase of illness
• •Current active medical condition that affect brain anatomy, neurochemistry, or function, e.g. liver insufficiency, kidney insufficiency, cardiovascular problems, systemic infections, cancer, hypothyroidism, auto-immune diseases, and any brain disorder (seizure disorder, stroke, dementia, degenerative neurologic diseases)
• •History of any brain diseases, including seizures, stroke, meningitis, encephalitis, dementia, degenerative brain diseases, and serious head injury with loss of consciousness
• •Family history of hereditary neurologic disorder
• •Floating metallic objects in the body
• •Pregnancy
• •Exposure to regular use of anti-inflammatory drugs in the last one month
• •Excessive exercise, consumption of caffeinated beverages or alcohol, high-fat meals 12 hours before testing
• •History of tobacco, alcohol, or drug abuse or dependence.
• •History of allergic reaction to vaccination or serious allergic reaction to shellfish or egg allergy