Safety and Efficacy of Cariprazine as an Adjunctive to Antidepressant Therapy in Major Depressive Disorder

Exclusion Criteria

• •Principal DSM-IV-TR-based diagnosis of an axis I disorder, other than MDD,
• •Women who are pregnant, or planning to become pregnant or breastfeed during the study or not practicing reliable contraception that will continue through out the study.
• •History of meeting DSM-IV-TR criteria for:
• •1. Depressive episode with psychotic or catatonic features.
• •2. Manic, hypomanic or mixed episode, including bipolar disorder and substance induced manic, hypomanic or mixed episode.
• •3. Schizophrenia, schizoaffective, or other psychotic disorder.
• •4. Obsessive-compulsive disorder.
• •5. Bulimia or anorexia nervosa.
• •6. Dementia, amnesic, or other cognitive disorder.
• •7. Mental retardation.
• •Participants considered a suicide risk.