Clinical Trials in Philadelphia

Showing 2641-2660 of 20,904 trials

TAS-102, Irinotecan, and Bevacizumab for the Treatment of Pre-treated Metastatic or Unresectable Colorectal Cancer, the TABAsCO Study

NCT04109924

This phase II trial studies how well TAS-102, irinotecan, and bevacizumab work in treating patients with pre-treated colorectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). Drugs used in chemotherapy, such as TAS-102, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Irinotecan may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with bevacizumab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Giving TAS-102, irinotecan, and bevacizumab may work better in treating patients with colorectal cancer compared to traditional chemotherapy and bevacizumab.

Advanced Colorectal CarcinomaMetastatic Colon AdenocarcinomaMetastatic Rectal Adenocarcinoma+24 more

Roswell Park Cancer Institute42 participantsStarted Dec 2019

Tampa, Florida, United States • New Brunswick, New Jersey, United States • Buffalo, New York, United States +1 more locations

Enrolling By Invitation< 1 mile

A Long-Term Follow-Up Basket Study for Participants Treated With SynKIR Chimeric Antigen Receptor (CAR) T Cell Product

NCT06701201

The primary purpose of this study is to monitor potential long-term risks associated with the administration of SynKIR CAR T cell products.

Cancer

Verismo Therapeutics60 participantsStarted Jan 2025

Denver, Colorado, United States • Atlanta, Georgia, United States • Westwood, Kansas, United States +3 more locations

TAS-102, Irinotecan, and Bevacizumab for the Treatment of Pre-treated Metastatic or Unresectable Colorectal Cancer, the TABAsCO Study

A Long-Term Follow-Up Basket Study for Participants Treated With SynKIR Chimeric Antigen Receptor (CAR) T Cell Product

Find Trials by Condition in Philadelphia

Vape Use Among Younger & Older Smokers

S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery

A Study to Assess the Efficacy and Safety of Solriamfetol in Subjects With ADHD (FOCUS)

Tafasitamab and Rituximab for Front-Line Treatment of Post-Transplant Lymphoproliferative Disorder

A Comparative Effectiveness Study of Major Glycemia-lowering Medications for Treatment of Type 2 Diabetes

An Open-label Study of Ozanimod in Moderate to Severe Ulcerative Colitis in Clinical Practice

HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma

Study of the Aliviado DSD Caregiving Mastery Program

Study of Natriuretic Peptide Receptor 1 (NPR1) Antagonist in Adult Patients With Postural Orthostatic Tachycardia Syndrome (POTS)

A Long-Term Study of Bivamelagon in Participants With Hypothalamic Obesity (HO)

EFS of the CardioMech MVRS

A Study to Evaluate INCA036873 in Participants With Advanced Solid Tumors and Hematological Malignancies

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

A Study to Evaluate the Efficacy and Safety of Povorcitinib (INCB054707) in Participants With Moderate to Severe Hidradenitis Suppurativa

Registry of Patients With AQP4+ NMOSD Treated With Alexion C5 Inhibitor Therapies

Study of ATX-01 in Participants With DM1

Homeless Veterans and Peer Whole Health Coaching

EMUs: Enhanced Monitoring Using Sensors After Surgery