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Vape Use Among Younger & Older Smokers | Clinical Trials | Clareo Health

RECRUITING

Vape Use Among Younger & Older Smokers

Factors That Affect Differential Switching and Patterns of ENDS Use Among Younger and Older Smokers: A Mixed Methods Approach

NCT07214168•Abramson Cancer Center at Penn Medicine

View on ClinicalTrials.gov

Summary

The study aims to recruit 100 current cigarette smokers (50 young adults ages 21-34; 50 older adults ages 35-65) who have tried vaping or are currently vaping (dual users). The study will examine the trajectories in tobacco use (cigarettes and/or ENDS), including the nuanced differences in ENDS use (i.e., detailed device characteristics, user preferences, patterns of use), according to smoker age group.

Eligibility

Age

21 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Male and female cigarette smokers who are between 21 and 65 years of age.
•Self-report having vaped at least once in the last six months (i.e. tried vaping) or are currently vaping.
•Self-report smoking at least 5 filtered cigarettes per week for at least the last 12 months.
•Not currently undergoing smoking cessation treatment or planning to quit prior to enrollment in the study.
•Able to attend 3 in-person visits in the Philadelphia area.
•Willing to smoke a cigarette in a ventilated smoking laboratory at each in-person visit.
•Capable of giving informed consent, which includes compliance with the requirements and restrictions listed in the combined consent and HIPAA form.
•Able to communicate fluently in English (i.e., speaking, writing, and reading).

Exclusion Criteria

•Smoking Behavior
•Use of any nicotine containing products other than cigarettes or ENDS. Participants reporting isolated use of other nicotine containing products less than 5 times per month are eligible to participate.
•Alcohol and Drug Use
•History of substance abuse (other than nicotine) in the past 12 months and/or currently receiving medical treatment for substance abuse. Attendance at alcoholics anonymous or narcotics anonymous meetings will not be considered medical treatment for the purposes of this protocol.
•Current alcohol consumption that exceeds 25 standard drinks/week.
•Medical
•Women, including all individuals assigned as female at birth, who are pregnant, breast feeding, or planning a pregnancy over the duration of the study period.
•Any psychiatric disorder that (as determined by the Principal Investigator) would interfere with study participation
•Serious or unstable medical condition. Applicable conditions will be evaluated on a case-by-case basis by the Principal Investigator.
•General Exclusion
+3 more criteria

Locations (1)

Center for Interdisciplinary Research on Nicotine Addiction

Philadelphia, Pennsylvania, United States

Key Dates

Start Date

September 5, 2025

Primary Completion Date

July 1, 2026

Completion Date

July 1, 2026

Last Updated

February 10, 2026

Enrollment

100

ESTIMATED participants

Conditions

Smoking CigaretteSmoking BehaviorsVapingVaping Behaviors

Contacts

Valentina Goren, MRA

CONTACT

215-746-3602 vsoup@pennmedicine.upenn.edu

Catherine Kreider, MSW

CONTACT

215-746-2631 cathk@pennmedicine.upenn.edu

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Cannabis UseTHC+3 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 10, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Vape Use Among Younger & Older Smokers

Inclusion Criteria

Exclusion Criteria

Smoking Cessation Before Bronchoscopy or CT-guided Puncture

Cannabis THC Potency, Metabolism, and Cognitive Impairment in Young Adults

Behavioral Intervention for Youth to Promote Vaping Cessation

Early Detection of Vaping-related Vascular Diseases

rTMS-concurrent Behavioral Priming for Reducing Smoking Cravings

Nicotine Patch Plus Nicotine Mouth Spray Versus Nicotine Reduction for Vaping Cessation