Clinical Trials in Philadelphia

Showing 2661-2680 of 20,904 trials

TAS-102, Irinotecan, and Bevacizumab for the Treatment of Pre-treated Metastatic or Unresectable Colorectal Cancer, the TABAsCO Study

NCT04109924

This phase II trial studies how well TAS-102, irinotecan, and bevacizumab work in treating patients with pre-treated colorectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). Drugs used in chemotherapy, such as TAS-102, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Irinotecan may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with bevacizumab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Giving TAS-102, irinotecan, and bevacizumab may work better in treating patients with colorectal cancer compared to traditional chemotherapy and bevacizumab.

Advanced Colorectal CarcinomaMetastatic Colon AdenocarcinomaMetastatic Rectal Adenocarcinoma+24 more

Roswell Park Cancer Institute42 participantsStarted Dec 2019

Tampa, Florida, United States • New Brunswick, New Jersey, United States • Buffalo, New York, United States +1 more locations

Active Not RecruitingPhase 3< 1 mile

Testing the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer

NCT04340141

This phase III trial compares perioperative chemotherapy (given before and after surgery) versus adjuvant chemotherapy (given after surgery) for the treatment of pancreatic cancer that can be removed by surgery (removable/resectable). Chemotherapy drugs, such as fluorouracil, irinotecan, leucovorin, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving chemotherapy before and after surgery (perioperatively) may work better in treating patients with pancreatic cancer compared to giving chemotherapy after surgery (adjuvantly).

Pancreatic Adenosquamous CarcinomaResectable Pancreatic AdenocarcinomaPancreatic Cancer

Alliance for Clinical Trials in Oncology358 participantsStarted Oct 2020

Birmingham, Alabama, United States • Fairhope, Alabama, United States • Mobile, Alabama, United States +450 more locations

TAS-102, Irinotecan, and Bevacizumab for the Treatment of Pre-treated Metastatic or Unresectable Colorectal Cancer, the TABAsCO Study

Testing the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer

Find Trials by Condition in Philadelphia

Osimertinib Plus Savolitinib in EGFRm+/MET+ NSCLC Following Prior Osimertinib

Efficacy + Safety of Liposome Cyclosporine A to Treat Bronchiolitis Obliterans Post Double Lung Transplant (BOSTON-2)

SPEARHEAD-3 Pediatric Study

Amplatzer Amulet LAAO vs. NOAC

A Study to Assess the Efficacy and Safety of Solriamfetol in Subjects With ADHD (FOCUS)

The Golazo® Peripheral Atherectomy System for a Safe and Effective Atherectomy (GREAT Trial)

A Phase 1/2 Trial of ARV-471 Alone and in Combination With Palbociclib (IBRANCE®) in Patients With ER+/HER2- Locally Advanced or Metastatic Breast Cancer

HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma

A Study of Barzolvolimab in Patients With Atopic Dermatitis

A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis, Progressive Forms of Multiple Sclerosis or Refractory Myasthenia Gravis (MG) (Breakfree-2)

Early Feasibility Study of the Supira System in Patients Undergoing HRPCI

An Open-Label ProSpective MultiCENTer Study to Evaluate Safety and Tolerability of Dry Powder Inhaled Treprostinil in PH

A Trial Investigating the Safety, Tolerability and Efficacy of TransCon PTH Administered Daily in Adults With Hypoparathyroidism

The GLIOMAX Study: MT027 Allogeneic CAR-T for Recurrent Glioma

FX Shoulder Prospective Clinical Study

A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of IMG-007 in Adult Alopecia Areata Participants

Homeless Veterans and Peer Whole Health Coaching

Avapritinib Rollover Study