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A Long-Term, Prospective, Observational, Registry of Patients With Anti-Aquaporin 4 Antibody-Positive (AQP4+) Neuromyelitis Optica Spectrum Disorder (NMOSD) Treated With Alexion Complement Component 5 (C5) Inhibitor Therapies (ALXN-C5IT)
Long-term, multicenter, multinational, observational, registry of patients with AQP4+ NMOSD that is designed to collect data on clinical outcomes and safety in patients prescribed Alexion C5 inhibitor therapies (C5IT). The registry will also collect data on patient reported outcomes (PROs), quality of life (QoL), and targeted AQP4+ NMOSD therapies used to provide evidence on the real-world impact of ALXN-C5IT on patients with AQP4+ NMOSD.
At the time of enrollment in the Registry, participant records will be queried for retrospective information about the participant's medical history and AQP4+ NMOSD treatment history for the time period beginning 1 year prior to ALXN-C5IT initiation through Registry enrollment. The duration of data collection for the Registry will be approximately 5 years from the day the last participant is enrolled.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Clinical Trial Site
Washington D.C., District of Columbia, United States
Research Site
Boston, Massachusetts, United States
Clinical Trial Site
Chapel Hill, North Carolina, United States
Clinical Trial Site
Columbus, Ohio, United States
Clinical Trial Site
Plano, Texas, United States
Clinical Trial Site
Milwaukee, Wisconsin, United States
Clinical Trial Site
Buenos Aires, Argentina
Clinical Trial Site
Buenos Aires, Argentina
Clinical Trial Site
Buenos Aires, Argentina
Clinical Trial Site
Buenos Aires, Argentina
Start Date
February 1, 2024
Primary Completion Date
March 1, 2030
Completion Date
March 1, 2030
Last Updated
February 10, 2026
122
ESTIMATED participants
Lead Sponsor
Alexion Pharmaceuticals, Inc.
NCT07410039
NCT06620809
NCT03900221
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
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