Clinical Trials in Boston

Showing 6621-6640 of 13,548 trials

A Phase 1b Study of IV PRM151 in Patients With Idiopathic Pulmonary Fibrosis (IPF)

NCT01254409

The aims of the study are to assess safety, tolerability, the pharmacokinetic profile, and the pharmacodynamic profile of multiple doses of PRM-151 administered IV to IPF patients.

Idiopathic Pulmonary Fibrosis

Hoffmann-La Roche21 participantsStarted Mar 2011

Boston, Massachusetts, United States • Durham, North Carolina, United States • Leiden, Netherlands

UNKNOWNPhase 3< 1 mile

Mino-Lok Therapy (MLT) for the Treatment of CRBSI/CLABSI

NCT02901717

This is a Phase 3, multi-center, randomized, open-label, assess-blind study to determine the efficacy and safety of MLT, a novel antibiotic lock therapy that combines minocycline with edetate disodium in 25% ethanol solution as an adjuctive therapy for the treatment of catheter-related or central line associated bloodstream infection (CRBSI/CLABSI). Approximately 144 subjects who have been diagnosed with CRBSI/CLABSI and who meet all necessary criteria for the study will be randomized in a 1:1 ratio to 1 of 2 treatment arms: * MLT Arm: Mino-Lok therapy; or * Control Arm: Antibiotic lock (±heparin). The antibiotic lock (ALT) should be comprised of the best available therapy at the sites based on standard institutional practices or recommendations from the Infectious Diseases Society of America (IDSA) guidelines.

Catheter-related Infections

Leonard-Meron Biosciences, Inc.144 participantsStarted Feb 2018

Washington D.C., District of Columbia, United States • Gainesville, Florida, United States • Hines, Illinois, United States +19 more locations

A Phase 1b Study of IV PRM151 in Patients With Idiopathic Pulmonary Fibrosis (IPF)

Mino-Lok Therapy (MLT) for the Treatment of CRBSI/CLABSI

Find Trials by Condition in Boston

A Study to Compare BMS-936558 to the Physician's Choice of Either Dacarbazine or Carboplatin and Paclitaxel in Advanced Melanoma Patients That Have Progressed Following Anti-CTLA-4 Therapy (CheckMate 037)

Inhaled Nitric Oxide for Preventing Progression in COVID-19

An Observational Study of Long-term Outcomes of HIV-1 Infection in Persons Who Become HIV-1 Infected After Enrollment in HIV-1 Vaccine Trials

Efficacy and Safety of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Kidney Disease

Supported Employment Demonstration

Docetaxel and Cyclophosphamide Compared to Anthracycline-Based Chemotherapy in Treating Women With HER2-Negative Breast Cancer

A Study to Assess the Efficacy and Safety of XP23829 in Subjects With Moderate-to-Severe Chronic Plaque-Type Psoriasis

Compare Efficacy/Safety of Repeat Doses of Ferumoxytol With Iron Sucrose in CKD Subjects With IDA and on Hemodialysis

A Study to Assess Efficacy and Safety of HL036 in Subjects With Dry Eyes

Integrase and Maraviroc Intensification in Neurocognitive Dysfunction (InMIND)

Olaparib Tablets as a Treatment for Ovarian Cancer Subjects With Different HRD Tumor Status

The Product Surveillance Registry REVERSE Post Approval Study

Biological and Clinical Effects of Palbociclib With Ovarian Suppression and Letrozole in the Neoadjuvant Treatment of Breast Cancer

A Study of Budigalimab (ABBV-181) in Participants With Advanced Solid Tumors

A Safety, Tolerability, and Pharmacokinetics Study of a Single Intravenous Injection of Recombinant Coagulation Factor VIII Fc - Von Willebrand Factor - XTEN Fusion Protein (rFVIIIFc-VWF-XTEN) (BIVV001) in Previously Treated Adults With Severe Hemophilia A (EXTEN-A)

Rollover Study for Continuing NBI-98854 Administration in Pediatric Subjects With Tourette Syndrome

SMS Maama Project COVID-19

Revealed Versus Concealed Cerebroplacental Ratio