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Clareo Health | Lung Cancer Clinical Trials in Boston | 649 Studies

Clinical Trials Lung CancerBoston

Lung Cancer Clinical Trials in Boston

Find 649 clinical trials for lung cancer near Boston, Massachusetts. Connect with research centers in your area.

All Lung Cancer trials nationwide All trials in Boston

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RecruitingNot yet recruitingActive, not recruitingEnrolling by invitationCompletedTerminated

Phase

Early phase 1Phase 1Phase 1–2Phase 2Phase 2–3Phase 3Phase 4Not applicable

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Showing 41-60 of 649 trials

RecruitingA Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung CancerThe purpose of this study is to assess if adding LY3537982 (olomorasib) in combination with standard of care anti-cancer drugs is more effective than standard of care in…NCT06119581·Huntsville, Alabama and 414 others

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Data from ClinicalTrials.govTerms

Active not recruitingA Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid TumorsThe main purpose of the study is to assess whether the study drug, LY4066434, is safe and tolerable when administered to participants with locally advanced or metastatic solid…NCT06607185·Birmingham, Alabama and 44 others

TerminatedFeasibility Study of Enhanced MRI for Early Stage Non Small Cell Lung Cancer (NSCLC)This is a pilot study. A pilot study is done with a small number of participants to see if a technique works before using it in a larger research study.NCT01799135·Boston, Massachusetts and 1 other

TerminatedA Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid TumorsThis study will test the safety of a drug called PF-08046049/SGN-BB228 in participants with melanoma and other solid tumors that are hard to treat or have spread through the body.NCT05571839·Los Angeles, California and 36 others

CompletedA Molecular Profiling Study of Patients With EGFR Mutation-positive Locally Advanced or Metastatic NSCLC Treated With OsimertinibA multicentre, open-label, single-arm, molecular profiling study of patients with EGFR mutation-positive locally advanced or metastatic NSCLC treated with osimertinib.NCT03239340·Athens, Georgia and 25 others

CompletedCombination of RAD001 and Erlotinib in Patients With Advanced Non Small Cell Lung Cancer Previously Treated Only With ChemotherapyThis study aims to assess the value of combined treatment with RAD001 and erlotinib in patients with advanced Non Small Cell Lung Cancer treated only with chemotherapy as systemic…NCT00456833·Atlanta, Georgia and 13 others

RecruitingPhase 1/2 Study of Intravenous Injection of STX-003 in Advanced Solid Tumors as Monotherapy or in Combination With PembrolizumabProtocol Title: Phase 1/2, Open-label, Multi-center, First-in-human Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Anti-tumor Activity of STX-003…NCT07751042·Scottsdale, Arizona and 3 others

Active not recruitingA Study to Investigate the Efficacy and Safety of Trastuzumab Deruxtecan as the First Treatment Option for Unresectable, Locally Advanced/Metastatic Non-Small Cell Lung Cancer With HER2 MutationsDESTINY-Lung04 will investigate the efficacy and safety of Trastuzumab Deruxtecan (T-DXd) versus Standard of Care (SoC) as first-line treatment of Non-Small Cell Lung Cancer…NCT05048797·Anchorage, Alaska and 129 others

RecruitingA Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)This is a multi-site, open-label, dose-finding study, consisting of Parts 1, 2a, and 2b to investigate the combination of BNT326 with pumitamig (also known as BNT327 or PM8002) in…NCT07111520·Los Angeles, California and 85 others

CompletedA Study of XL184 (Cabozantinib) With or Without Erlotinib in Subjects With Non-Small Cell Lung Cancer (NSCLC)The study consisted of a Phase 1 dose escalation/dose de-escalation portion to determine a safe and tolerable combination dose(s) of cabozantinib and erlotinib, and a Phase 2…NCT00596648·Anchorage, Alaska and 12 others

TerminatedStudy of Inlexisertib (DCC-3116) in Participants With RAS/MAPK Pathway Mutant Solid TumorsThis is a multicenter, open label, first in human (FIH) study of inlexisertib as monotherapy, and in combination with trametinib, binimetinib, or sotorasib in participants with…NCT04892017·Boston, Massachusetts and 9 others

Active not recruitingStudy of Amivantamab, a Human Bispecific EGFR and cMet Antibody, in Participants With Advanced Non-Small Cell Lung CancerThe purpose of study is to evaluate the safety, pharmacokinetics, and preliminary efficacy of Amivantamab as a monotherapy and in combination with lazertinib, and to determine the…NCT02609776·Duarte, California and 68 others

Active not recruitingStudy of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid TumorsThis is a multicenter Phase 1b, open-label study to assess safety, tolerability, preliminary efficacy, and pharmacokinetics (PK) of cabozantinib taken in combination with…NCT03170960·Gilbert, Arizona and 123 others

Active not recruitingSafety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLCThis is a First-in-Human Phase IA/IB/II open label dose escalation study of intravenous (IV) administration of ONC-392, a humanized anti-CTLA4 IgG1 monoclonal antibody, as single…NCT04140526·Springdale, Arkansas and 36 others

Active not recruitingA Study Evaluating AB248 Alone or in Combination With Pembrolizumab in Adult Patients With Solid TumorsThis is a phase I, First-in-Human (FIH), open-label study to evaluate the safety, tolerability, pharmacokinetic (PK) profile, and preliminary efficacy of AB248 as monotherapy OR…NCT05653882·Duarte, California and 19 others

Active not recruitingCombination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C MutationStudy CA239-0010 is an open-label, Phase 2 clinical trial evaluating the clinical efficacy of adagrasib in combination with pembrolizumab and chemotherapy in the first-line…NCT05609578·Fountain Valley, California and 93 others

CompletedAZD9291 Versus Gefitinib or Erlotinib in Patients With Locally Advanced or Metastatic Non-small Cell Lung CancerTo assess the efficacy and safety of AZD9291 versus a standard of care epidermal growth factor receptor tyrosine kinase inhibitor in patients with locally advanced or Metastatic…NCT02296125·Anaheim, California and 169 others

TerminatedRO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast CancerThis randomized phase I/II trial studies the side effects and the best dose of RO4929097 (gamma-secretase/Notch signalling pathway inhibitor RO4929097) when given together with…NCT01217411·Boston, Massachusetts and 1 other

Active not recruitingAssess Efficacy & Safety of Selumetinib in Combination With Docetaxel in Patients Receiving 2nd Line Treatment for v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Positive NSCLCThe purpose of this study is to assess the efficacy of selumetinib in combination with docetaxel (75mg/m2) vs placebo in combination with docetaxel (75mg/m2) in patients with…NCT01933932·Aurora, Colorado and 196 others

TerminatedAn Investigational Immuno-therapy Study to Test Combination Treatments in Patients With Advanced Non-Small Cell Lung CancerThe purpose of this study is to determine whether Nivolumab, in combination with other therapies, is effective in patients with advanced Non-Small Cell lung cancerNCT02750514·Duarte, California and 49 others

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