Lead Sponsor

Seagen, a wholly owned subsidiary of Pfizer

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•All Parts: Participants must have disease that is relapsed, refractory, or intolerant to standard of care. Participants must have histologically or cytologically confirmed metastatic malignancy.
•Participants must have one of the following tumor types:
•* Parts A and B: Participants must have metastatic or unresectable cutaneous melanoma.
•* Part C: Participants must have one of the following tumor types:
•* Cutaneous Melanoma
•* Non-small Cell Lung Cancer (NSCLC)
•* Colorectal Cancer (CRC)
•* Pancreatic Cancer
•* Mesothelioma
•A pre-treatment biopsy or submission of archival tissue is required
•For participants with cutaneous melanoma
•* Must have been previously treated with an anti-programmed death-1 (anti-PD-1) or anti-programmed death ligand-1 (anti-PD-L1) agent given alone or with other therapies.
•* Participants with a targetable BRAF mutation must have been treated with, been intolerant of, or been deemed ineligible to receive treatment with BRAF/MEK targeted therapy prior to study entry.
•Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0 or 1
•Measurable disease per RECIST v1.1 at baseline

•History of another malignancy within 3 years before the first dose of study drug, or any evidence of residual disease from a previously diagnosed malignancy. Exceptions are malignancies with a negligible risk of metastasis or death.
•Active central nervous system metastases or leptomeningeal disease. Participants with previously treated brain metastases may participate provided they are:
•* clinically stable for at least 4 weeks prior to study entry after brain metastasis treatment,
•* they have no new or enlarging brain metastases,
•* and are off of corticosteroids prescribed for symptoms associated with brain metastases for at least 7 days prior to the first dose of study drug.
•Prior therapies cannot include any drugs targeting CD228 or 4-1BB
•Immunotherapy, biologics, and/or other approved or investigational antitumor treatment that is not completed 4 weeks prior to first dose of study drug, or within 2 weeks prior to the first dose of study drug if the underlying disease has progressed on treatment
•Melanoma subtypes including acral, uveal, and mucosal are excluded

Related studies

NCT06043817 · Non-Small Cell Lung Cancer, NSCLC, and more

NCT07541924 · Colorectal Cancer Screening, Colonic Polyps/Colonoscopy/Colorectal Neoplasms, and more

NCT07144280 · Non-small Cell Carcinoma, Non-Small Cell Lung Cancer Metastatic, and more

NCT07431827 · Non-small Cell Lung Cancer

NCT06758401 · Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung, and more

A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid Tumors