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Browse 1,725 clinical trials for depression. Find studies that match your criteria and connect with research centers.
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NCT01498107
This pilot study investigates a new platform for supporting online interventions for common mental health problems called SilverCloud. It was developed from insights into interactive system design to address the problem of high attrition rates and poor engagement with online interventions. Through a range of methods, the study considers the role of four design strategies in engaging users in cognitive behavioural therapy. A service-based study, it concentrates on a clinical population with mild or moderate depression. Clinical outcome measures will be taken pre and post intervention use; demographic data of who did and did not choose the intervention collected, patterns of usage will be extracted from the log data and analysed; and qualitative interviews will be done to understand the relationship between patterns of usage and levels of engagement. The findings will be used to inform further developments of this and other online interventions and contribute to the development of methods for assessing online interventions. The objectives of the pilot study are: * To evaluate engagement with the online intervention in a realistic primary mental health care setting * Assess engagement from multiple perspectives, including clinical efficacy and interaction design * Contribute to further development of the online intervention * Support preparation for a full-scale clinical trial Research questions include: * Does the online intervention decrease symptoms of depression? * Who chooses to use the online intervention? * What are the patterns of use of the online intervention? * How successful are the four design principles, personal, interactive, supportive and social, in supporting engagement?
NCT01652391
Insufficient cognitive control over emotional distracters is characteristic for major depressive disorder (MDD). Hypoactivation of the dorsolateral prefrontal cortex (dlPFC) is associated with this deficit. In this study the investigators assess the effect of an enhancement of dlPFC activity in MDD patients by anodal transcranial direct current stimulation (tDCS) on cognitive control. In a double-blinded, balanced randomized, sham-controlled crossover trial the investigators determine the effect of a single-session tDCS to the left dlPFC on cognitive control in MDD patients and healthy controls. To assess the cognitive control the investigators use a delayed response working memory (DWM) task with pictures of varying valence presented during the delay period.