Depression Clinical Trials

Showing 801-820 of 3,654 trials

Generative Artificial Intelligence Intervention and Individual Psychological Counseling on Emotional Distress in Young Adults

NCT06992180

This randomized controlled trial aims to evaluate the effectiveness of an AI-based mental health chatbot, Emohaa, in reducing symptoms of depression, anxiety, insomnia, and academic burnout among young adults experiencing emotional distress. A total of 222 participants will be randomly assigned to one of three groups: (1) AI chatbot intervention, (2) traditional counseling, or (3) waitlist control. The study spans six time points from baseline through one-month follow-up. Primary and secondary outcomes will be measured via validated self-report questionnaires. The intervention is delivered entirely online through a WeChat-integrated platform, ensuring high accessibility and scalability.

Depression, Anxiety

Central University of Finance and Economics, China222 participantsStarted May 2025

RECRUITING

Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression

NCT05329441

Despite the prevalence and significant public health concern over depression among adolescents, up to 40% of depressed adolescents do not respond to first-line antidepressants (herein termed treatment non-response, TNR). The goal of this project is to recruit and assess 160 treatment-seeking depressed adolescents and test whether acute stress impacts peripheral levels of inflammation and downstream levels of glutamate in corticolimbic regions previously associated with depression, whether these stress-related biomarkers predict TNR to a 12-week trial of either fluoxetine or escitalopram, and whether these stress-related biomarkers predict 18-month clinical course.

Depression in Adolescence

University of California, Los Angeles160 participantsStarted Jul 2023

Los Angeles, California, United States

Generative Artificial Intelligence Intervention and Individual Psychological Counseling on Emotional Distress in Young Adults

Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression

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