Anxiety Clinical Trials in Philadelphia

Showing 1-20 of 45 trials

Effect of cTBS on Startle and TMS-evoked BOLD

NCT07415772

The right dorsolateral prefrontal cortex (dlPFC) is increasingly being targeted with transcranial magnetic stimulation (TMS) to reduce anxiety expression; however, there is little mechanistic evidence supporting an optimized treatment protocol. Thus, the objective of the current project is to develop an interleaved TMS/fMRI that can assess the effect of neuromodulatory (potentially therapeutic) TMS protocols on neural and behavioral measures related to anxiety expression. PUBLIC HEALTH RELEVANCE: These results will yield direct evidence that 1 Hz and cTBS modulate brain activity associated with anxiety expression and regulation, thus informing novel TMS based anxiety treatments.

Anxiety

University of Pennsylvania140 participantsStarted Jul 2026

Philadelphia, Pennsylvania, United States

ACTIVE_NOT_RECRUITINGNA< 1 mile

Supporting Family Caregivers of Persons With Dementia

NCT05336344

Based on preliminary work, whereby investigators examined pain management challenges and needs of caregivers of hospice patients with dementia, this team designed a cognitive behavioral intervention informed by the relational model of stress, entitled ENCODE (Empowering Caregivers of Patients with Dementia) to assist caregivers in effectively identifying and communicating their pain management challenges and needs. The investigators propose a 5-year randomized clinical trial in which caregivers of patients with Alzheimer's Disease and Related Dementias (ADRD) will be randomly assigned to a group receiving standard hospice care with the addition of "friendly video-calls" providing social support (attention control group) or a group receiving standard hospice care with the addition of the ENCODE intervention (intervention group).

Caregiver Stress SyndromeAnxietyDepression

University of Pennsylvania412 participantsStarted Jul 2022

Philadelphia, Pennsylvania, United States

Effect of cTBS on Startle and TMS-evoked BOLD

Supporting Family Caregivers of Persons With Dementia

Anxiety Trials in Other Cities

Effect of (TaVNS) on Anxiety and Brain Function in Distressed Health Care Workers

Pregabalin in the Treatment of Patients With Generalized Anxiety Disorder (GAD).

Standardized Yoga & Meditation Program for Stress Reduction for Adolescents With Irritable Bowel Syndrome

A Clinical Study That Will Measure How Well SEP-363856 Works and How Safe it is in Adults With Generalized Anxiety Disorder

SPD503 in Subjects Aged 6-17 Years With Generalized Anxiety Disorder (GAD), Separation Anxiety Disorder (SAD), or Social Phobia (SoP)

Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder

Multisite Virtual Reality Intervention for Speech Anxiety

mHealth Mindfulness With Patients With Serious Illness and Their Caregivers

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease

Pramipexole to Enhance Social Connections

A Study of Escitalopram in the Treatment of Children and Adolescents With Generalized Anxiety Disorder

Building Community Capacity for Disability Prevention for Minority Elders (Positive Minds - Strong Bodies)

Healthy Lifestyle Intervention for High-Risk Minority Pregnant Women

Targeting Attention Orienting to Social Threat to Reduce Social Anxiety in Youth

The PRISM Intervention for Adolescents and Young Adults Receiving Hematopoietic Cell Transplantation

Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer

Efficacy and Safety of Pregabalin vs Placebo for Generalized Anxiety Disorder (GAD) Symptoms in Subjects Discontinuing Benzodiazepine Treatment and Remaining 6 Weeks on Study Medication, Free From Benzodiazepine Use.

Long-Term Retention of Gadolinium in Bone

Other Conditions in Philadelphia