Clinical Trials in Pittsburgh

Showing 9621-9640 of 16,007 trials

LTFU for Gene Transfer Subjects With Hemophilia B

NCT00515710

Several subjects enrolled in a multi-site, gene transfer clinical study to evaluate the intrahepatic administration of AAV2-hFIX16 vector for the treatment of severe hemophilia B between 2001 and 2009. As the US FDA has established guidelines for the long-term follow-up (LTFU) of subjects receiving investigational gene therapy products, this protocol seeks to characterize the clinical outcome and the type and seriousness of adverse events following the AAV gene transfer. The primary study tools will consist of annual history/physical examination and blood tests, as well as periodic liver ultrasound, to characterize clinical outcomes. Where possible, data will be obtained for up to 15 years following hepatic AAV2-hFIX16 gene transfer.

Hemophilia B

Spark Therapeutics, Inc.4 participantsStarted Aug 2007

Philadelphia, Pennsylvania, United States • Pittsburgh, Pennsylvania, United States

COMPLETEDPhase 2< 1 mile

Alisertib in Treating Young Patients With Recurrent or Refractory Solid Tumors or Leukemia

NCT01154816

This phase II trial is studying the side effects of and how well alisertib works in treating young patients with relapsed or refractory solid tumors or leukemia. Alisertib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

HepatoblastomaPreviously Treated Childhood RhabdomyosarcomaRecurrent Childhood Acute Lymphoblastic Leukemia+8 more

Children's Oncology Group118 participantsStarted Feb 2011

Birmingham, Alabama, United States • Birmingham, Alabama, United States • Little Rock, Arkansas, United States +102 more locations

LTFU for Gene Transfer Subjects With Hemophilia B

Alisertib in Treating Young Patients With Recurrent or Refractory Solid Tumors or Leukemia

Find Trials by Condition in Pittsburgh

A Study of the Efficacy and Safety of Apremilast (CC-10004) in Subjects With Moderate to Severe Plaque Psoriasis of the Scalp

Community Central Line Infection Prevention Trial

A Phase 3 Clinical Trial of Intravenous Sodium Thiosulfate in Acute Calciphylaxis Patients

ICON1: Treatment Decisions and Outcomes in Pediatric Refractory ITP

Study of Carboplatin/Paclitaxel With or Without Investigational Drug (CS-7017) in Subjects With Metastatic Non-small Cell Lung Cancer

Neurologic Complications in Spinal Deformity Surgery - Extension

A Long-Term Extension Study of OnabotulinumtoxinA (BOTOX®) for Urinary Incontinence Due to Neurogenic Detrusor Overactivity

Glucagon Ready to Use (RTU) in Subjects With Hyperinsulinemic Hypoglycemia After Bariatric Surgery

Direct Gloving Strategy: A Cluster-randomized Trial

Selinexor in Combination With Fludarabine and Cytarabine in Patients With Refractory or Relapsed Acute Myeloid Leukemia

To Assess the Safety and Activity of GBR 830, Compared to Placebo, in Adults With Moderate-to-severe Atopic Dermatitis

Study in Participants With Acute Migraines Headaches

Study to Evaluate the Safety and Efficacy of Filgotinib and Lanraplenib in Adults With Lupus Membranous Nephropathy (LMN)

Nortriptyline for Idiopathic Gastroparesis

Lenalidomide in Treating Older Patients With Acute Myeloid Leukemia Who Have Undergone Stem Cell Transplant

A Study of Equivalence of Generic Ingenol Mebutate Gel 0.05% and Picato Gel 0.05% in Subjects With Actinic Keratosis

Effectiveness and Acceptability of Stellate Ganglion Block for Posttraumatic Stress Disorder Symptoms - Effectiveness

Study Comparing OsseoSpeed™ Implants of Two Different Lengths in the Upper and Lower Posterior Jaw