Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of SAR440340 (Anti-IL-33 mAb) in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)

Inclusion Criteria

• •Participants with a diagnosis of chronic obstructive pulmonary disease (COPD) for at least 1 year (based on Global Initiative for Chronic Obstructive Lung Disease \[GOLD\] definition).
• •Participants with moderate-to-severe COPD (post-bronchodilator forced expiratory volume in 1 second \[FEV1\]/forced vital capacity \[FVC\] less than \[\<\] 70 percent (%) and post-bronchodilator FEV1% predicted \<80%, but greater than equal to \[\>=\] 30%).
• •Participants with COPD assessment test (CAT) score \>=10 at Screening.
• •Participants with reported history of signs and symptoms of chronic bronchitis (chronic productive cough for 3 months in the year up to screening in a participant in whom other causes of chronic cough \[e.g., gastroesophageal reflux, chronic rhinosinusitis, bronchiectasis\] had been excluded).
• •Participants with a documented history (e.g., medical record verification) of \>=2 moderate exacerbations or \>=1 severe exacerbation within the year prior to screening. A moderate exacerbation was defined as an acute exacerbation of COPD (AECOPD) requiring systemic corticosteroids (oral, intravenous, or intramuscular) and/or treatment with antibiotics (however, use of antibiotics alone does not qualify as a "moderate exacerbation" unless documentation was available that use of antibiotics was necessary for treatment of worsening symptoms of COPD). A severe exacerbation was defined as an AECOPD that required a hospitalization.
• •Participants with standard of care background therapy, for 3 months and at a stable dose for at least 1 month, including either:
• •Double therapy: Long acting beta agonist (LABA) + Long acting muscarinic agonist (LAMA) or inhaled corticosteroid (ICS) + LABA or ICS + LAMA.
• •or
• •Triple therapy: LABA + LAMA + ICS.
• •Current or former smokers with a smoking history of \>=10 packs/year.