Clinical Trials in Cleveland

Showing 2821-2840 of 19,775 trials

Longitudinal Study for Central Nervous System Vasculitis

NCT05734404

Primary central nervous system vasculitis (CNSV) is a potentially fatal, single-organ vasculitis that often involves a spectrum of neurologic complications, including strokes, cognitive and speech impairment, visual loss, dementia, and encephalopathy. The purpose of this study is to establish a research cohort to investigate the disease process, treatments, and patient outcomes in CNSV.

Central Nervous System VasculitisCNS VasculitisCNSV+1 more

University of Pennsylvania40 participantsStarted Mar 2023

Rochester, Minnesota, United States • Cleveland, Ohio, United States • Philadelphia, Pennsylvania, United States +3 more locations

Active Not RecruitingPhase 1< 1 mile

Safety and Preliminary Efficacy of BNT314 in Cancer Patients With Malignant Solid Tumors

NCT06150183

The purpose of this first-in-human study is to find out if BNT314 is safe when it is used alone in patients with different types of cancer. This is a dose escalation study in which patients will be assigned to multiple dose levels (DLs) of BNT314 given alone. By escalating the dose with a small group of patients, the Maximum Tolerated Dose which is the highest dose with acceptable safety and manageable side effects, or the maximum administered dose will be investigated.

Advanced Malignant Solid Tumor

BioNTech SE41 participantsStarted Nov 2023

Grand Rapids, Michigan, United States • Huntersville, North Carolina, United States • Cleveland, Ohio, United States +11 more locations

Longitudinal Study for Central Nervous System Vasculitis

Safety and Preliminary Efficacy of BNT314 in Cancer Patients With Malignant Solid Tumors

Find Trials by Condition in Cleveland

Long-term Safety and Efficacy Study of MT-8554 in Postmenopausal Women With Vasomotor Symptoms

Preventing Extension of Oligoarticular Juvenile Idiopathic Arthritis JIA (Limit-JIA)

Mindfulness-based Intervention for Depressive Symptoms Sent Via Text (MINDSET)

Impact of Surgical Coaching on Resident ObGyn Laparoscopic Skills

A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures

Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder

A Study of Abemaciclib (LY2835219) in Participants With Non-Small Cell Lung Cancer or Breast Cancer

Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease

Non-healing Diabetic Foot Ulcers Treated With Standard Care With or Without BR-AM

HKI-272 for HER2-Positive Breast Cancer and Brain Metastases

Morphine or Ketamine for Analgesia

Evaluating the Role of Inflammation in Neonatal Epileptogenesis

Gene Replacement Therapy Clinical Trial for Participants With Spinal Muscular Atrophy Type 1

A Study to Learn About the Effects and Safety of RTA 408 (Omaveloxolone) in People Aged 16 to 40 With Friedreich's Ataxia

Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living With HIV: A Feasibility Study

Study to Evaluate the Pharmacokinetics, Safety and Tolerability of Intravenous Secukinumab in Patients With GCA or PMR

Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With Tumors With Oncogene Amplifications

Deep Brain Stimulation of Treatment-Resistant Bipolar Depression