Clinical Trials in Cleveland

Showing 2841-2860 of 19,775 trials

Safety and Preliminary Efficacy of BNT314 in Cancer Patients With Malignant Solid Tumors

NCT06150183

The purpose of this first-in-human study is to find out if BNT314 is safe when it is used alone in patients with different types of cancer. This is a dose escalation study in which patients will be assigned to multiple dose levels (DLs) of BNT314 given alone. By escalating the dose with a small group of patients, the Maximum Tolerated Dose which is the highest dose with acceptable safety and manageable side effects, or the maximum administered dose will be investigated.

Advanced Malignant Solid Tumor

BioNTech SE41 participantsStarted Nov 2023

Grand Rapids, Michigan, United States • Huntersville, North Carolina, United States • Cleveland, Ohio, United States +11 more locations

RECRUITINGPhase 2< 1 mile

A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures

NCT07219407

This is a clinical research study for an investigational drug called RAP-219 in patients with Refractory Focal Epilepsy. This study is being conducted to determine RAP-219 Long- term safety and open-label antiseizure activity in patients with Refractory Focal Epilepsy.

Focal EpilepsyEpilepsyRefractory Focal Epilepsy+3 more

Rapport Therapeutics Inc.30 participantsStarted Dec 2025

Boise, Idaho, United States • Rochester, Minnesota, United States • New York, New York, United States +4 more locations

Safety and Preliminary Efficacy of BNT314 in Cancer Patients With Malignant Solid Tumors

A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures

Find Trials by Condition in Cleveland

Mindfulness-based Intervention for Depressive Symptoms Sent Via Text (MINDSET)

Longitudinal Study for Central Nervous System Vasculitis

Abatacept for the Treatment of Giant Cell Arteritis

Preventing Extension of Oligoarticular Juvenile Idiopathic Arthritis JIA (Limit-JIA)

Clinical Transcriptomics in Systemic Vasculitis (CUTIS)

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

A Phase 1 Study in Patients With HPV16+ Recurrent/ Metastatic Head and Neck Squamous Cell Carcinoma

A Trial to Learn How the Combination of Fianlimab With Cemiplimab and Chemotherapy Works Compared With Cemiplimab and Chemotherapy for Treating Adult Patients With Advanced Non-small Cell Lung Cancer

HKI-272 for HER2-Positive Breast Cancer and Brain Metastases

Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study

A Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of Emicizumab in Participants With Mild or Moderate Hemophilia A Without FVIII Inhibitors

Study of Gemcitabine, Cisplatin, AB680 and AB122 During First Line Treatment of Advanced Biliary Tract Cancers (QUIC)

Efficacy and Safety of Apitegromab in Patients With Later-Onset Spinal Muscular Atrophy Treated With Nusinersen or Risdiplam

HBRN: Immune Regulation and Costimulation in Natural History and Therapeutic Outcome of Chronic Hepatitis B

An Efficacy and Safety Study of Basimglurant (NOE-101) in Patients With Trigeminal Neuralgia.

Study of the CHK1 Inhibitor BBI-355, an ecDNA-directed Therapy (ecDTx), and the RNR Inhibitor BBI-825, in Subjects With Tumors With Oncogene Amplifications

Safety and Efficacy Study of VNX001 Compared to Its Individual Components (Lidocaine and Heparin) or Placebo in Subjects With IC/BPS

Non-healing Venous Leg Ulcers Treated With Standard Care With or Without BR-AC