Evaluating the Role of Inflammation in Neonatal Epileptogenesis

Inclusion Criteria

• •For participants in the acute symptomatic seizure group:
• •Neonates \<44 weeks corrected age at seizure onset
• •Seizures due to acute brain injury
• •Parent(s) who are English or Spanish literate (with assistance of interpreter)
• •Neonates that are born \> 37 weeks and \<44 weeks postmenstrual age at enrollment
• •Consultation by the pediatric neurology inpatient service due neonatal paroxysmal events, with normal neurologic examination and ultimate diagnosis of non-epileptic spells on continuous video-EEG (ordered for clinical purposes, not for research) OR consultation for hypoxic ischemic encephalopathy in neonates undergoing therapeutic hypothermia, with early exit from therapy owing to normal neurologic examination, normal continuous video-EEG and uncertain diagnosis of encephalopathy.
• •Neonates requiring neurologic consultation for mild hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia, with normal examination, cEEG, and neuroimaging upon rewarming.