Clinical Trials in Boston

Showing 1961-1980 of 17,836 trials

Evaluation of PET Probe [68Ga]CBP8 in the Detection of Radiation Induced Tissue Injury

NCT04485286

The goal of this study is to investigate the efficacy of \[68Ga\]CBP8 to detect collagen deposition in radiation induced tissue injury.

Lung CancerRadiation FibrosisRadiation Induced Lung Injury+1 more

Massachusetts General Hospital72 participantsStarted Jul 2020

Boston, Massachusetts, United States

TERMINATEDPhase 2< 1 mile

MBG453 in Lower Risk MDS

NCT04823624

This research study is assessing the efficacy of MBG-453, a humanized monoclonal antibody, in treating myelodysplastic syndromes (MDS). The name of the study drug involved in this study is MBG453.

Myelodysplastic Syndromes

Massachusetts General Hospital10 participantsStarted Jan 2022

Boston, Massachusetts, United States • Boston, Massachusetts, United States • Boston, Massachusetts, United States

RECRUITINGPhase 1< 1 mile

A Clinical Trial to Assess COM503 in Participants With Advanced Solid Malignancies

NCT06759649

The overall goal of this first-in-human (FIH) clinical trial is to learn about the safety and dosing of COM503 when given alone or in combination with zimberelimab in participants with advanced solid tumors. The primary objectives of this study are: * To assess the safety and tolerability of COM503 as monotherapy and COM503 in combination with zimberelimab in participants with advanced solid tumors. * To identify the maximum tolerated dose (MTD) / maximum administered dose (MAD) and/or the recommended phase 2 dose (RP2D) of COM503 as monotherapy and in combination with zimberelimab in participants with advanced solid tumors.

NeoplasmCancer, Malignant Tumors

Compugen Ltd200 participantsStarted Jan 2025

New Haven, Connecticut, United States • Boston, Massachusetts, United States • Grand Rapids, Michigan, United States +8 more locations

Evaluation of PET Probe [68Ga]CBP8 in the Detection of Radiation Induced Tissue Injury

MBG453 in Lower Risk MDS

A Clinical Trial to Assess COM503 in Participants With Advanced Solid Malignancies

Find Trials by Condition in Boston

A Frontline Therapy Trial in Participants With Advanced Classical Hodgkin Lymphoma

Positron Emission Tomography (PET) Imaging of Thrombosis

Lactiplantibacillus Plantarum 299v Probiotic Supplementation in Patients With Diabetic Macular Edema

Sparsentan for the Treatment of VEGF Signaling Pathway Inhibitor-Associated Proteinuria

Star Matrix vs Autogenous Graft for Gingival Augmentation: Split-Mouth RCT

Plasma and Radiologic Biomarkers of Response to ECP in Lung Transplant Recipients With CLAD

Couples Lived Experience

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis

To Assess the Effectiveness and Safety of Zepzelca in Adult Patients With Extensive Stage Small Cell Lung Cancer (SCLC)

Phase 2a Study to Assess the Efficacy,Safety and Tolerability of GIA632 in Adult Participants With Moderate to Severe Atopic Dermatitis

A Trial of Etelcalcetide in Pediatric Participants With Secondary Hyperparathyroidism and Chronic Kidney Disease on Hemodialysis

A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Anti-tumour Activity of IPN01203 in Adults With Locally Advanced or Metastatic Solid Tumours Exposed to Immune Checkpoint Inhibitor Therapies

A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

The HIgh-fidelity Hydraulic couPling Upper-arm Cuff Assessment of Limits, Safety, and Effectiveness (HIPULSE) Trial (Cardiac Output Study)

SMP-3124LP in Adults With Advanced Solid Tumors

A Study to Compare Safety and Efficacy of High Doses of Eteplirsen in Participants With Duchenne Muscular Dystrophy (DMD) (MIS51ON)