Clinical Trials in Boston

Showing 4481-4500 of 13,548 trials

Effect of Combined Morphine and Duloxetine on Chronic Pain

NCT03249558

A double-blind, randomized, and placebo-controlled clinical study examining whether duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), could enhance opioid analgesia and reduce overall opioid use. Positive outcomes will help improve the overall effectiveness of clinical opioid therapy and reduce unnecessary opioid dose escalation.

Chronic Low Back PainChronic Neck Pain

Massachusetts General Hospital81 participantsStarted Mar 2018

Boston, Massachusetts, United States

COMPLETEDNA< 1 mile

Psychological Intervention for Caregivers of Patients With Malignant Gliomas

NCT03735498

This research study is evaluating a psychological intervention for caregivers of loved ones with malignant gliomas.

Malignant Glioma

Massachusetts General Hospital13 participantsStarted Feb 2019

Boston, Massachusetts, United States

COMPLETEDNA< 1 mile

Focal MR-Guided Focused Ultrasound Treatment of Localized Intermediate Risk Prostate Lesions

NCT01657942

The hypothesis of this study is that focal treatment with ExAblate MRgFUS has the potential to be an effective non-invasive treatment for intermediate risk, organ-confined prostate lesions, with a low incidence of morbidity. The study hypothesis will be tested by measuring treatment-related safety and initial effectiveness parameters in the ExAblate MRgFUS treated patients, as described above.

Localized Intermediate Risk Prostate Lesions

InSightec101 participantsStarted Oct 2013

Duarte, California, United States • Los Angeles, California, United States • Stanford, California, United States +6 more locations

Effect of Combined Morphine and Duloxetine on Chronic Pain

Psychological Intervention for Caregivers of Patients With Malignant Gliomas

Focal MR-Guided Focused Ultrasound Treatment of Localized Intermediate Risk Prostate Lesions

Find Trials by Condition in Boston

Increasing Lung Transplant Availability Using Normothermic Ex Vivo Lung Perfusion (EVLP) at a Dedicated EVLP Facility

A Study of Ipatasertib Plus Palbociclib and Fulvestrant Versus Placebo Plus Palbociclib and Fulvestrant in Hormone Receptor Positive and HER2 Negative Locally Advanced Unresectable or Metastatic Breast Cancer

A Study to Test Whether Taking BI 1358894 for 8 Weeks Helps Adults With Post-traumatic Stress Disorder

Onvansertib in Combination With Abiraterone and Prednisone in Adult Patients With Metastatic Castration-Resistant Prostate Cancer

A Phase 1, Dose Escalation Study to Assess the Safety and Tolerability of ASP9853 With Either Docetaxel or Paclitaxel in Patients With Advanced Non-hematologic Malignancies

Lumateperone for the Prevention of Relapse in Patients With Schizophrenia

Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma

Study of the Efficacy and Safety of Lemborexant in Subjects 55 Years and Older With Insomnia Disorder (SUNRISE 1)

Combined Behavioral and Pharmacological Intervention for Cardiovascular Risk Reduction in Diabetic Patients

Study of GSK3845097 in Previously Treated Participants With Advanced Synovial Sarcoma and Myxoid/Round Cell Liposarcoma

Study to Investigate LP352 in Subjects With Developmental and Epileptic Encephalopathies

A Study to Assess the Long Term Effect, Safety and Metabolism of a Solifenacin Liquid Suspension in Participants 5 to 18 Years of Age With Neurogenic Detrusor Overactivity

Natural History Study in Pediatric Patients With MYBPC3 Mutation-associated Cardiomyopathy

Efficacy, Safety, Pharmacodynamic, and Pharmacokinetics Study of Olipudase Alfa in Patients With Acid Sphingomyelinase Deficiency

Study to Evaluate the Safety, Tolerability,Pharmacokinetics, and Antitumor Activity of a Thorium-227 Labeled Antibody-chelator Conjugate Alone and in Combination With Darolutamide, in Patients With Metastatic Castration Resistant Prostate Cancer

A Study of MK-1484 as Monotherapy and in Combination With Pembrolizumab (MK-3475) In Advanced or Metastatic Solid Tumors (MK-1484-001)

Ganitumab in Locally Advanced Unresectable Adenocarcinoma of the Pancreas