Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Biogen
Age
18–85
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Diagnosis of acute ischemic stroke.
Score of ≥6 points on the National Institute of Health Stroke Scale (NIHSS) at Screening.
At least 1 acute infarct with largest diameter of more than 2 cm on Baseline brain diffusion-weighted imaging (DWI).
Participants who have received reperfusion therapy may be eligible to participate but must meet all eligibility criteria and perform the Baseline study magnetic resonance imaging (MRI) after reperfusion therapy has been completed.
Subjects of childbearing potential must practice effective contraception during the study and be willing and able to continue contraception for at least 3 months after their dose of study treatment.
You may not be if
Presence of any intracranial hemorrhage (ICH) on head computed tomography (CT) or non-petechial ICH on screening MRI.
Stroke isolated to the brainstem.
Presence of coma
Expected to die OR unable to be evaluated within 5 days.
Hypotension requiring the use of intravenous (IV) vasopressor support or systolic blood pressure \<90 mmHg at the time of randomization.
Known prior treatment with natalizumab.
Immunocompromised subjects, as determined by the Investigator.
History of progressive multifocal leukoencephalopathy (PML).
Contraindications to MRI, e.g., implanted pacemaker or other contraindicated implanted metal devices, history of or risk for side effects from gadolinium, or claustrophobia that cannot be medically managed.
Clareo Health | Effect of Natalizumab on Infarct Volume in Acute Ischemic Stroke
