Clinical Trials in Boston

Showing 4461-4480 of 17,836 trials

Breath Biomarkers for Sleep Loss and Circadian Timing

NCT03980340

Insufficient sleep has both health and safety risks, but currently there are no quick, accurate and inexpensive ways to measure sleep deficiency. The current study aims to use a cutting-edge technology, small molecule analysis (e.g. metabolomics), to detect compounds in breath that reliably change with sleep-wake state and those whose levels vary by time of day.

Shift-Work Sleep DisorderShift Work Type Circadian Rhythm Sleep DisorderSleep Disorders, Circadian Rhythm+8 more

Brigham and Women's Hospital5 participantsStarted Jan 2021

Boston, Massachusetts, United States

COMPLETEDPhase 1< 1 mile

Study of DKN-01 and Gemcitabine/Cisplatin in Patients With Carcinoma to Primary to the Intra- or Extra-Hepatic Biliary System or Gallbladder

NCT02375880

DKN-01 is a humanized monoclonal antibody (Mab) with neutralizing activity against Dkk-1 and is being developed as an anti-neoplastic agent. This study is designed to evaluate the safety, tolerability, pharmacokinetics, and anti-tumor activity of DKN-01 in combination with gemcitabine and cisplatin in patients with carcinoma primary to the intra- or exta-hepatic biliary system or gallbladder.

Carcinoma of Intrahepatic and Extra-hepatic Biliary SystemCarcinoma of GallbladderBile Duct Cancer+1 more

Leap Therapeutics, Inc.51 participantsStarted Jun 2015

Los Angeles, California, United States • New Haven, Connecticut, United States • Boston, Massachusetts, United States +6 more locations

Breath Biomarkers for Sleep Loss and Circadian Timing

Study of DKN-01 and Gemcitabine/Cisplatin in Patients With Carcinoma to Primary to the Intra- or Extra-Hepatic Biliary System or Gallbladder

Find Trials by Condition in Boston

A Study to Evaluate the Incidence of Clinically Suspicious Lambert-Eaton Myasthenic Syndrome (LEMS) in Subjects Diagnosed With Small Cell Lung Cancer (SCLC)

Effective Interventions to Overcome Severe Gag Reflex

Study to Evaluate EP547 in Subjects With Cholestatic Pruritus Due to Primary Biliary Cholangitis or Primary Sclerosing Cholangitis

VentaProst Versus Conventionally-Administered Aerosolized Epoprostenol in Patients Undergoing Cardiac Surgery With CPB

Nerve Excitability in Cisplatin-Induced Peripheral Neuropathy

Connect® MM- The Multiple Myeloma Disease Registry

Responses to Message Source and Presentation Using Psychophysiology

Strength for U in Relationship Empowerment

Portico Next Generation Approval Study

Topical Ruxolitinib Evaluation in Chronic Hand Eczema

Trial of LAVA-1207 in Patients With Therapy Refractory Metastatic Castration Resistant Prostate Cancer (mCRPC) Resistant Prostate Cancer

Efficacy and Safety of TenoMiR in Lateral Epicondylitis

Study to Assess the Effects of PTC857 Treatment in Participants With Amyotrophic Lateral Sclerosis ALS

A Study of INCB099280 in Combination With Adagrasib in Adults With Advanced Solid Tumors Harboring a KRASG12C Mutation

Transorb™ Self-Gripping Resorbable Mesh in High-risk Subjects Undergoing Open Repair of Ventral Hernia

Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate)

The NODE-202 Study (Study of Etripamil Nasal Spray in Pediatric Patients)

A Study to Evaluate LTI-03 in Newly Diagnosed Idiopathic Pulmonary Fibrosis (IPF) Patients