Clinical Trials in Boston

Showing 3061-3080 of 17,836 trials

Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients

NCT03202641

The goal of this interventional crossover study, in intubated and mechanically ventilated Acute Respiratory Distress Syndrome (ARDS) patients, is to compare two positive end-expiratory pressure (PEEP) titration techniques regarding: respiratory mechanics, gas exchange, changes in aeration, ventilation/perfusion matching its impact on cardiac function, especially the right heart (RH). The PEEP titration techniques are: PEEP selection based on low PEEP/high FiO2 table ("PEEPARDSnet") and lung recruitment maneuver (LRM) plus PEEPdec titration based on the best compliance of the respiratory system("PEEPLRM").

ARDS, HumanLung Injury, AcuteRespiratory Distress Syndrome+4 more

Massachusetts General Hospital2 participantsStarted Jun 2019

Boston, Massachusetts, United States

Active Not RecruitingPhase 3< 1 mile

A Study to Evaluate Mavacamten in Adolescents With Symptomatic Obstructive Hypertrophic Cardiomyopathy

NCT06253221

The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of mavacamten in adolescent patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM).

Cardiomyopathy, Hypertrophic

Bristol-Myers Squibb44 participantsStarted Apr 2024

Birmingham, Alabama, United States • Phoenix, Arizona, United States • Los Angeles, California, United States +44 more locations

Open Lung Strategy, Gas Distribution and Right Heart Function in ARDS Patients

A Study to Evaluate Mavacamten in Adolescents With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Find Trials by Condition in Boston

Prolonged Hypoxic Breathing in Healthy Volunteers: a Safety Study

Elevate! : An Elderly Breast Cancer Cohort Study

fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

Study of Vimseltinib (DCC-3014) in Patients With Advanced Tumors and Tenosynovial Giant Cell Tumor

Multisite Virtual Reality Intervention for Speech Anxiety

HAELO: A Phase 3 Study to Evaluate NTLA-2002 in Participants With Hereditary Angioedema (HAE)

A Study of GSK5764227 in Participants With. Advanced Solid Tumors (EMBOLD PanTumor-101)

Vitamin D and Omega-3 Hypertension Trial (VITAL Hypertension)

A Study to Test if Fremanezumab is Effective in Preventing Chronic Migraine in Participants 6 to 17 Years of Age

FORCE-TJR: Improving Orthopedic Outcomes Through a National TJR Registry

Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of EP262 in Subjects With Chronic Spontaneous Urticaria

A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)

Pancreatic Cancer Detection Consortium

STEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight Loss

HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease

Safety and Pharmacokinetics of LPX-TI641 in Atopic Dermatitis and Psoriasis

A Multicentre Observational Study to Evaluate Clinical Outcomes of the G7 Acetabular System

An Observational LTFU Study for Patients Previously Treated With Autologous ex Vivo Gene Therapy for ADA-SCID