Clinical Trials in Boston

Showing 2341-2360 of 8,503 trials

Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

NCT06136546

This study is a mechanistic randomized controlled trial that investigates whether inhibition of tumor necrosis factor signaling via intravenous infusion of infliximab improves psychomotor speed and executive functioning in depressed individuals who exhibit an inflammatory phenotype.

Depressive Disorder, MajorInflammation

Massachusetts General Hospital100 participantsStarted Jan 2025

Boston, Massachusetts, United States

TERMINATEDPhase 2< 1 mile

Evaluating the Safety and Efficacy of Deucravacitinib Compared to Placebo Hidradenitis Suppurativa (HS).

NCT05997277

The study is a randomized, proof of concept study. 30 patients aged 18 and over with HS will be included in this single center, randomized, double-blind, parallel-group study. Dosage of deucravacitinib will be given according to the investigational regimen as follows: 6 mg po bid for 16 weeks. The study compromises a 4-week screening period, a 16-week study period, and a 4-week follow-up period. The follow-up period consists of a follow-up phone call 4 weeks after the last study drug dose.

Hidradenitis Suppurativa

Beth Israel Deaconess Medical Center7 participantsStarted Nov 2023

Boston, Massachusetts, United States

Active Not RecruitingNA< 1 mile

Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD

NCT04591392

Evaluation of the safety and efficacy of the reSept ASD Occluder to treat patients with clinically significant secundum atrial septal defect

Heart Septal DefectHeart Septal Defects, AtrialHeart Defects, Congenital+4 more

atHeart Medical250 participantsStarted Mar 2021

Birmingham, Alabama, United States • Los Angeles, California, United States • Thousand Oaks, California, United States +29 more locations

Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

Evaluating the Safety and Efficacy of Deucravacitinib Compared to Placebo Hidradenitis Suppurativa (HS).

Safety and Efficacy Study of reSept ASD Occluder for Treating Secundum ASD

Find Trials by Condition in Boston

Treating Parkinson's Disease Through Transplantation of Autologous Stem Cell-Derived Dopaminergic Neurons

Immunotherapy Before Transplantation for Skin Cancer Prevention in Organ Transplant Recipients

Experiment to Assess Preferences for Novel Hormonal Therapy and Androgen-deprivation Therapy in Prostate Cancer Patients

Vagus Nerve Stimulation(VNS) As Treatment For Fibromyalgia Patients

Predictive Value of Coronary Heart Disease (CHD) Biomarkers for CHD Death

Tolerability and Feasibility Pilot Clinical Study of a Large-Diameter Nerve Cap for Protecting and Preserving Terminated Nerve Ends

Precision-T: A Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies

e-OPRA Implant System for Lower Limb Amputees

Pre-exposure Prophylaxis (PrEP) for Health

Circulating Tumor DNA Testing in Predicting Treatment for Patients With Stage IIA Colon Cancer After Surgery

A Study of Copanlisib Combined With Rucaparib in Patients With Metastatic Castration-resistant Prostate Cancer

Repurposing Nucleoside Reverse Transcriptase Inhibitors for Treatment of AD

A Study of PF-07260437 in Advanced or Metastatic Solid Tumors

AltaValve Pivotal Trial

A Phase III, Crossover Trial Evaluating the Efficacy and Safety of KVD900 (Sebetralstat) for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients With Hereditary Angioedema (HAE)

Retrospective Clinical Trial Comparing Radiologists' Diagnosis Accuracy in Lung Cancer Screening Population With and Without the Help of an AI/ML Tech-based SaMD

HOPE-B: Trial of AMT-061 in Severe or Moderately Severe Hemophilia B Patients