Clinical Trials in Boston

Showing 2341-2360 of 17,836 trials

Dapagliflozin in Active Lupus Nephritis

NCT07323524

Lupus nephritis is a chronic and life-threatening autoimmune cause of kidney disease that predominately impacts young people and can lead to kidney failure. Sodium-glucose co-transporter-2 inhibitors, including dapagliflozin, are known to improve outcomes for people with other causes of chronic kidney disease. This pilot and feasibility randomized clinical trial will test the use of dapagliflozin versus placebo in addition to standard of care treatment for patients with early and active lupus nephritis, a group who has not been included in past trials.

Lupus Nephritis (LN)

Brigham and Women's Hospital33 participantsStarted Feb 2026

Boston, Massachusetts, United States • Boston, Massachusetts, United States

COMPLETEDPhase 1/2< 1 mile

An Open-Label Phase 1/2 Study of Itacitinib in Combination With Osimertinib in Subjects With Non-Small Cell Lung Cancer

NCT02917993

The purpose of this study is to evaluate the safety and tolerability of itacitinib in combination with osimertinib in subjects with locally advanced or metastatic non-small cell lung cancer (NSCLC).

Lung Cancer

Incyte Corporation59 participantsStarted Dec 2016

La Jolla, California, United States • San Francisco, California, United States • Whittier, California, United States +28 more locations

Dapagliflozin in Active Lupus Nephritis

An Open-Label Phase 1/2 Study of Itacitinib in Combination With Osimertinib in Subjects With Non-Small Cell Lung Cancer

Find Trials by Condition in Boston

Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer

A Prospective Sub-Study of the Global Hypophosphatasia Registry

Expanded Access Protocol (EAP) for Nonconforming (NC) Afami-cel

ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)

Intermuscular Coherence as a Biomarker for ALS

A Study of BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations

Prospective Validation of an EHR-based Pancreatic Cancer Risk Model

SPEARHEAD-3 Pediatric Study

CorEvitas Generalized Pustular Psoriasis (GPP) Drug Safety and Effectiveness Registry

CorEvitas International Adolescent Alopecia Areata (AA) Drug Safety and Effectiveness Registry

A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of IMG-007 in Adult Alopecia Areata Participants

Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)

A Trial Investigating the Safety, Tolerability and Efficacy of TransCon PTH Administered Daily in Adults With Hypoparathyroidism

Study of Efficacy and Safety of Investigational Treatments in Patients With Moderate to Severe Hidradenitis Suppurativa

A Study of Vobramitamab Duocarmazine in Participants With Metastatic Castration Resistant Prostate Cancer and Other Solid Tumors

A Study Evaluating the Efficacy and Safety of Vixarelimab in Participants With Idiopathic Pulmonary Fibrosis and in Participants With Systemic Sclerosis-Associated Interstitial Lung Disease

Avapritinib Rollover Study

Global Registry for Endovascular Aortic Treatment (GREAT)