ExCrossV Multi Site Trial for Vascularized High Risk Keratoplasty

Exclusion Criteria

• •History of Stevens-Johnson syndrome or ocular pemphigoid
• •Ocular or periocular malignancy
• •Non-healing epithelial defect of at least 0.5x0.5 mm in host corneal bed lasting ≥6 weeks preoperatively
• •Uncontrolled glaucoma
• •Change in topical corticosteroid regimen within 14 days of transplantation
• •Use of systemic immunosuppressive for indication other than corneal graft rejection
• •Participation in another simultaneous medical investigation or trial
• •Pregnancy (positive pregnancy test) or lactating
• •Pre-menopausal women not using adequate contraception (Reliable intrauterine devices, hormonal contraception or a spermicide in combination with a barrier method)
• •Ocular infection within 30 days prior to study entry.
• •Presence of anterior chamber intraocular lens
• •Active uveitis within 90 days prior to the study entry.
• •No ocular surgery or procedure within 90 days prior to the study entry or concomitant to the study procedure.