Clinical Trials in Boston

Showing 2261-2280 of 8,503 trials

Testing the Addition of an Anti-cancer Drug, Elimusertib (BAY 1895344) ATR Inhibitor, to the Chemotherapy Treatment (Gemcitabine) for Advanced Pancreatic and Ovarian Cancer, and Advanced Solid Tumors

NCT04616534

This phase I trial identifies the best dose, possible benefits and/or side effects of gemcitabine in combination with elimusertib (BAY 1895344) in treating patients with pancreatic, ovarian, and other solid tumors that have spread to other places in the body (advanced). Gemcitabine is a chemotherapy drug that blocks the cell from making DNA and may kill tumor cells. elimusertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving gemcitabine and elimusertib in combination may shrink or stabilize cancer.

Advanced Fallopian Tube CarcinomaAdvanced Malignant Solid NeoplasmAdvanced Ovarian Carcinoma+19 more

National Cancer Institute (NCI)14 participantsStarted Jun 2021

Bethesda, Maryland, United States • Bethesda, Maryland, United States • Boston, Massachusetts, United States

Active Not RecruitingNA< 1 mile

Multi-Component Breath Alcohol Intervention

NCT06124898

This is the first stage of a three-stage, NIH-funded study to develop and test initially a multi-modal intervention concerning blood/breath alcohol concentration for young adults. The multimodal intervention will be made up of brief telehealth counseling and psychoeducation and use of three mobile technologies to facilitate moderate drinking. In the first stage of the study, we will conduct formative research to obtain input from the study population, test initially the telehealth version of the brief counseling and psychoeducation and to develop a simple, "low tech" approach to coaching participants to use the three mobile technologies in typical drinking situations. Participation will last approximately one month.

Alcohol UseAlcohol DrinkingDrinking Behavior

Northeastern University115 participantsStarted Nov 2023

Boston, Massachusetts, United States

Testing the Addition of an Anti-cancer Drug, Elimusertib (BAY 1895344) ATR Inhibitor, to the Chemotherapy Treatment (Gemcitabine) for Advanced Pancreatic and Ovarian Cancer, and Advanced Solid Tumors

Multi-Component Breath Alcohol Intervention

Find Trials by Condition in Boston

ThRombectomy In Mild Ischemic Stroke With a Visible Intracranial veSsel Occlusion

AMIE's Clinical Conversational Abilities in an Urgent Care Setting

Mycobacteriophage Treatment of Non-tuberculosis Mycobacteria

NUDGE-EHR Replication Trial at Mass General Brigham

Treatment of Pregnant Women With OUD

Parkinson's Foundation PD GENEration Genetic Registry

BCMA-directed CAR-T Cell Therapy in Adult Patients With Multiple Myeloma

Tools for Reducing Inequity in Acute Leukemia (TRIAL): Beta Testing

Rucaparib in Treating Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

A Study of the Drugs AGN-242428 and AGN-231868 in Participants With Dry Eye Disease

Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activity of ADCT-901 in Participants With Selected Advanced Solid Tumors

Safety and Efficacy Study of CFI-402411 in Subjects With Advanced Solid Malignancies

Study of Safety, Tolerability and Efficacy of PBGM01 in Pediatric Participants With GM1 Gangliosidosis

Stopping Aminosalicylate Therapy in Inactive Crohn's Disease

Efficacy & Safety of rAd-IFN Administered With Celecoxib & Gemcitabine in Patients With Malignant Pleural Mesothelioma

RecruitmEnt Assessed by eleCtRical Impedance Tomography

A RCT Evaluating the Clinical Benefit of a Silver Dressing in the Treatment of Venous Leg Ulcers