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Clareo Health | Melanoma Clinical Trials in Massachusetts | 363 Studies

Clinical Trials MelanomaMassachusetts

Melanoma Clinical Trials in Massachusetts

Find 363 clinical trials for melanoma near Massachusetts. Connect with research centers in your area.

All Melanoma trials nationwide All trials in Massachusetts

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Status

RecruitingNot yet recruitingActive, not recruitingEnrolling by invitationCompletedTerminated

Phase

Early phase 1Phase 1Phase 1–2Phase 2Phase 2–3Phase 3Phase 4Not applicable

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Showing 161-180 of 363 trials

CompletedTrial of Dacarbazine With or Without Genasense in Advanced MelanomaThis study is being performed to prospectively determine whether dacarbazine plus Genasense is significantly better than dacarbazine plus placebo in chemotherapy-naive patients…NCT00518895·Mobile, Alabama and 76 others

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Data from ClinicalTrials.govTerms

CompletedBoron Neutron Capture Therapy in Treating Patients With Glioblastoma Multiforme or Melanoma Metastatic to the BrainRATIONALE: Radiation therapy such as boron neutron capture therapy may kill tumor cells without harming normal tissue.NCT00039572·Boston, Massachusetts and 1 other

RecruitingA Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid TumorsThis is an open label, multicenter, phase 1/2 study to assess the safety/tolerability and preliminary clinical activity of STAR0602 as a single agent and in combination with…NCT05592626·Sacramento, California and 18 others

CompletedCarboplatin and Paclitaxel With or Without Sorafenib Tosylate in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by SurgeryThis randomized phase III trial studies carboplatin, paclitaxel, and sorafenib tosylate to see how well they work compared to carboplatin and paclitaxel in treating patients with…NCT00110019·Birmingham, Alabama and 218 others

CompletedA Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant MelanomaThis was a two-arm, double-blinded, randomized, Phase III study comparing dabrafenib and trametinib combination therapy to dabrafenib administered with a placebo (dabrafenib…NCT01584648·Scottsdale, Arizona and 120 others

Active not recruitingPD-1 Antibody Therapy + Infliximab for Metastatic MelanomaThe purpose of this research is to test the safety and effectiveness of the investigational combination of anti-Programmed Death (PD)-1 antibody therapy with or without LAG-3…NCT05034536·Boston, Massachusetts

CompletedSRK-181 Alone or in Combination With Anti-PD-(L)1 Antibody Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (DRAGON)This was a multi-center, open-label, Phase 1, first-in-human (FIH), dose-escalation, and dose expansion study to evaluate the safety, tolerability, pharmacokinetics (PK)…NCT04291079·Fullerton, California and 21 others

WithdrawnCombination of Anti-CD137 & Ipilimumab in Patients With MelanomaThe purpose of this study is to determine if BMS-663513 administered in combination with ipilimumab to patients with advanced malignant melanoma is safe and tolerableNCT00803374·Los Angeles, California and 6 others

CompletedComparison of AZD6244 in Combination With Dacarbazine Versus (vs) Dacarbazine Alone in BRAF Mutation Positive Melanoma PatientsTo assess the efficacy in terms of overall survival of AZD6244 in combination with dacarbazine, compared with dacarbazine alone, in first line patients with BRAF mutation positive…NCT00936221·Aurora, Colorado and 37 others

CompletedA Personal Cancer Vaccine (NEO-PV-01) w/ Nivolumab for Patients With Melanoma, Lung Cancer or Bladder CancerThe purpose of this study is to evaluate if the treatment with NEO-PV-01 + adjuvant in combination with nivolumab is safe and useful for patients with certain types of cancer.NCT02897765·Duarte, California and 8 others

CompletedGSK1120212 vs Chemotherapy in Advanced or Metastatic BRAF V600E/K Mutation-positive MelanomaThis is a two-arm, open-label, randomized Phase III study comparing single agent GSK1120212 to chemotherapy (either dacarbazine or paclitaxel) in subjects with Stage IIIc or Stage…NCT01245062·Tucson, Arizona and 111 others

CompletedA Study of Autogene Cevumeran (RO7198457) as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic TumorsThis is a Phase 1a/1b, open-label, multicenter, global, dose-escalation study designed to evaluate the safety, tolerability, immune response, and pharmacokinetics of autogene…NCT03289962·Scottsdale, Arizona and 32 others

TerminatedNiraparib in the Treatment of Patients With Advanced PALB2 Mutated TumorsThe purpose of this study is to further evaluate the efficacy and safety of niraparib in patients with locally advanced or metastatic solid tumors and a pathogenic or likely…NCT05169437·Yuma, Arizona and 79 others

CompletedStudy Comparing the Efficacy of MEK162 Versus Dacarbazine in Unresectable or Metastatic NRAS Mutation-positive MelanomaTwo-arm, randomized, prospective, open-label, multi-center, phase III study to compare the efficacy and safety of MEK162 (45 mg BID) versus dacarbazine (1000 mg/m2 IV every 3…NCT01763164·Fayetteville, Arkansas and 228 others

Active not recruitingIpilimumab With or Without Sargramostim in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by SurgeryThis randomized phase II trial is studying how well giving ipilimumab with or without sargramostim (GM-CSF) works in treating patients with stage III or stage IV melanoma that…NCT01134614·Birmingham, Alabama and 256 others

CompletedVaccination With Autologous, Lethally Irradiated Melanoma Cells Engineered by Adenoviral Mediated Gene Transfer to Secrete Granulocyte-Macrophage Stimulating Factor (GMSF)The purpose of this study is to see if the proposed therapy will delay or stop the progression of the participants skin cancer.NCT00809588·Boston, Massachusetts and 1 other

CompletedBiological Therapy in Treating Children With Refractory or Recurrent Neuroblastoma or Other TumorsRATIONALE: Biological therapies such as hu14.18-interleukin-2 fusion protein use different ways to stimulate the immune system and stop cancer cells from growing.NCT00003750·Little Rock, Arkansas and 58 others

CompletedRetinoblastoma Biomarker StudyRetinoblastoma is a rare pediatric ocular tumor caused by germline and/or somatic mutations in the tumor suppressor gene RB1.NCT00342797·Bethesda, Maryland and 3 others

CompletedDiagnostic Study to Predict the Risk of Developing Metastatic Cancer in Patients With Stage I or Stage II MelanomaRATIONALE: Diagnostic procedures that analyze surgically-removed tumor tissue and lymph node samples may help doctors identify patients with melanoma who are at risk for…NCT00049010·Chicago, Illinois and 26 others

CompletedImproving Patient and Caregiver Understanding of Risks and Benefits of Immunotherapy for Advanced CancerThe purpose of this study is to refine and pilot test educational material developed to educate and support patients receiving immunotherapy for advanced cancer.NCT04670445·Boston, Massachusetts

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