Hepatitis Clinical Trials

Showing 701-720 of 1,819 trials

Combi-elastography Assessment of Chronic Liver Disease Multi-center Study

NCT04625166

HITACH developed a new combi-elastography imaging technology combines shear wave imaging and strain imaging technology. In the study, not only the F index which is related to the stage of liver fibrosis can be obtained, but also the A index which is related to the stage of hepatitis can be obtained, which can not be obtained by other ultrasound devices.

Non Alcoholic Fatty LiverHepatitis BDrug-induced Liver Injury

Chinese PLA General Hospital880 participantsStarted Dec 2020

Beijing, Beijing Municipality, China

UNKNOWNNA

Tenofovir Alafenamide for HBV Prophylaxis in HBV(-) Liver Transplant Recipients With HBcAb+ Donors

NCT04703465

Liver transplantation is currently the only effective way to treat end-stage liver disease.The shortage of donor liver is still the major problem. Incidence of HBcAb+ varies between different regions. The HBcAb positive rate could be as high as 52% in China.HBcAb positive donor liver may enlarge donor pool and thus save ESLD patients. However, the use of HBcAb positive donor liver may induce HBV infection in hepatitis B negative recipient after liver transplantation. Tenofovir alafenamide (TAF) has better stability in plasma and higher liver targeting property in comparison with tenofovir (TDF), with an extra amide bond, which allows strong antiviral effect with much less doses and reducing the renal and bone injury. Our study intends to evaluate the efficacy and safety of HBV prophylaxis treatment of TAF in HBV negative patients after receiving HBcAb positive donor livers.

HBVLiver Transplant Disorder

RenJi Hospital30 participantsStarted Apr 2021

COMPLETEDPhase 1

Pharmacokinetics and Pharmacodynamics of Cilofexor in Adults With Normal and Impaired Hepatic Function

NCT02808312

The primary objective of this study is to evaluate the single-dose pharmacokinetics of cilofexor in adults with impaired hepatic function relative to matched, healthy controls with normal hepatic function.

Nonalcoholic Steatohepatitis (NASH)Primary Sclerosing Cholangitis (PSC)

Gilead Sciences57 participantsStarted Jul 2016

Miami, Florida, United States • Orlando, Florida, United States • Knoxville, Tennessee, United States +2 more locations

Combi-elastography Assessment of Chronic Liver Disease Multi-center Study

Tenofovir Alafenamide for HBV Prophylaxis in HBV(-) Liver Transplant Recipients With HBcAb+ Donors

Pharmacokinetics and Pharmacodynamics of Cilofexor in Adults With Normal and Impaired Hepatic Function

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Safety, Tolerability, Pharmacokinetics and Efficacy of LMB763 in Patients With NASH

The Tolerability , Pharmacokinetics and Pharmacodynamics Study of HEC96719 Tablets in Healthy Adult Subjects

LDT Combined With TDF to Improve EGFR Decreasing in Patients With Chronic Hepatitis B Treated With TDF

The Effectiveness and Safety of Tenofovir Alafenamide in the Treatment of Chronic Hepatitis B Patients With Mildly Elevated Alanine Aminotransferase and Significant Liver Injury.

Adaptive-design Dose Finding Study to Assess the Antiviral Efficacy and Safety of NIM811 Administered in Combination With Standard of Care (SOC) in Relapsed Hepatitis C Virus 1 (HCV-1) Infected Patients

Morbidity and Mortality of Hepatitis E Virus Infections in Belgium

Study to Evaluate the Pharmacokinetics of Firsocostat or Fenofibrate in Adults With Normal and Impaired Hepatic Function

The Ribavirin Pregnancy Registry

Integrating HCV and HIV Screening During the Era of HIV Antigen Testing

Safety and Efficacy of Different Antiviral Regimens for Hepatitis C Virus Relapse

Study to Evaluate the Pharmacokinetics of Tenofovir Alafenamide (TAF) in Adults With Normal Hepatic Function and Adults With Severe Hepatic Impairment

A Drug-drug Interaction Study Between Daclatasvir and Atazanavir/Ritonavir or Atazanavir/Cobicistat

Behavioral Science and Hepatitis C Screening Outreach

Pharmacokinetic Study of the HCV Protease Inhibitor Boceprevir and the HIV Integrase Inhibitor Raltegravir

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CLINICAL PROTOCOL to Investigate the Long-term Safety and Efficacy of Metreleptin in Various Forms of Partial Lipodystrophy

Study of Antiretroviral Therapy to Prevent HBV Intrauterine Infection