Depression Clinical Trials in New York

Showing 61-80 of 165 trials

1/2-Dopaminergic Dysfunction in Late-Life Depression (The D3 Study)

NCT04493320

Growing evidence suggests that dopamine contributes to key cognitive, emotional, and motor functions across the lifespan. In Late-Life Depression (LLD), dysfunction in these areas is common, predicts poor outcomes, and manifests as difficulties in motivation and effort along with cognitive and gait impairment. While studies of dopamine function in early and midlife depression primarily focus on individuals' ability to feel pleasure and respond to rewards, they often exclude the cognitive and physical function domains relevant for older adults despite a recognized decline in dopamine function with normal aging. The objectives of this collaborative R01 proposal between Columbia University/New York State Psychiatric Institute and Vanderbilt University Medical Center are to: 1) characterize dopaminergic dysfunction in LLD across cognitive, emotional, and motor domains at several levels of analysis (cellular Positron Emission Tomography \[PET\], circuit Magnetic Resonance Imaging \[MRI\], and behavioral / self-report); and 2) examine the responsivity of dopamine-related circuits and behavior to stimulation with carbidopa/levodopa (L-DOPA).

DepressionCognitive ImpairmentGait Impairment

New York State Psychiatric Institute5 participantsStarted Feb 2021

New York, New York, United States

COMPLETEDPHASE3< 1 mile

Clinical Trial Evaluating ITI-007 as an Adjunctive Therapy to Lithium or Valproate for the Treatment of Bipolar Depression

NCT02600507

The study will evaluate the efficacy and safety of ITI-007 adjunctive to lithium or valproate in a randomized, double-blind, parallel-group, placebo-controlled, multi-center study in patients diagnosed with Bipolar I or Bipolar II disorder having a major depressive episode.

Bipolar Depression

Intra-Cellular Therapies, Inc.529 participantsStarted Mar 2016

Rogers, Arkansas, United States • Cerritos, California, United States • Costa Mesa, California, United States +68 more locations

1/2-Dopaminergic Dysfunction in Late-Life Depression (The D3 Study)

Clinical Trial Evaluating ITI-007 as an Adjunctive Therapy to Lithium or Valproate for the Treatment of Bipolar Depression

Depression Trials in Other Cities

Just Do You Program for Young Adults With Serious Mental IIlness

Cornerstone Program for Transition-Age Youth Study Protocol for a Randomized Controlled Trial

NRX101 Glx Biomarker Validation Study

Antidepressant Response in Older Adults With Comorbid PTSD and MDD

Brain Imaging to Understand the Role of Inflammation in N-Acetyl Cysteine (NAC) Treatment of Bipolar Depression

Fluoxetine and Bupropion to Treat Patients With Depression and Alcoholism

Efficacy and Safety Study of SPD489 in Combination With an Antidepressant in the Treatment of Adults With Major Depressive Disorder

Building Community Capacity for Disability Prevention for Minority Elders (Positive Minds - Strong Bodies)

The Efficacy of a Depression Intervention for Adolescents With Depression and Sleep Disturbances

Open-label Long Term (52 Weeks) Safety and Tolerability of Agomelatine Sublingual Tablets in Major Depressive Disorder (MDD)

A Study Of The Efficacy And Safety Of CP-601,927 Augmentation Of Antidepressant Therapy In Major Depression

A Long Term Study of ALKS 5461 in the Treatment of Refractory Major Depressive Disorder (MDD)

A Clinical Trial of PRAX-114 in Participants With Major Depressive Disorder

Remote Bimanual Virtual Rehabilitation Post CVD

Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression

Depression Prevention Initiative - A Study of Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST) in School Settings

Safety and Tolerability of Single and Multiple Ascending Doses of GATE-101 in Normal Human Volunteers

Long Term Follow Up Study to COMP 001 And COMP 003 Trials (P-TRD LTFU)

Other Conditions in New York