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Clinical Trials Colorectal CancerTennessee

Colorectal Cancer Clinical Trials in Tennessee

Find 454 clinical trials for colorectal cancer near Tennessee. Connect with research centers in your area.

All Colorectal Cancer trials nationwide All trials in Tennessee

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RecruitingNot yet recruitingActive, not recruitingEnrolling by invitationCompletedTerminated

Phase

Early phase 1Phase 1Phase 1–2Phase 2Phase 2–3Phase 3Phase 4Not applicable

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Showing 21-40 of 454 trials

TerminatedStudy of MRTX1133 in Patients With Advanced Solid Tumors Harboring a KRAS G12D MutationA Phase 1/2 study of MRTX1133 in solid tumors harboring a KRAS G12D mutation.NCT05737706·Phoenix, Arizona and 13 others CompletedStudy of NK012 and 5-FU/LV in Solid Tumors Followed by Dose Expansion in Colorectal CancerThe primary objective is to determine the maximum tolerated dose/recommended phase II dose of the combination regimen of NK012 and 5-fluorouracil in patients with advanced solid…NCT01238939·Nashville, Tennessee Active not recruitingA Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid TumorsThe main purpose of the study is to assess whether the study drug, LY4066434, is safe and tolerable when administered to participants with locally advanced or metastatic solid…NCT06607185·Birmingham, Alabama and 44 others

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Data from ClinicalTrials.govTerms

RecruitingA Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal CancerThe purpose of this study is to evaluate the efficacy and safety of standard-of-care chemotherapy and bevacizumab with or without INCA33890 in the first-line treatment of…NCT07284849·Mobile, Alabama and 296 others

CompletedA Safety, Pharmacokinetic and Efficacy Study of NUC-3373 in Combination With Standard Agents Used in Colorectal Cancer TreatmentThis is a three-part study of NUC-3373 administered by intravenous (IV) infusion across two administration schedules, either as monotherapy or as part of various combinations with…NCT03428958·Boston, Massachusetts and 9 others

Not yet recruitingA Study of CLSP 5282 in HLA-A*03:01 Positive Adult Patients With Solid Tumors (SENTINEL-101)Phase 1, open-label, multicenter study to evaluate the safety, tolerability, PK, PD, and preliminary clinical activity of CLSP 5282 when administered to HLA A\*03:01-positive…NCT07650357·Durham, North Carolina and 3 others

RecruitingSafely Optimizing Body Weight With Mifomelatide (TCMCB07) in Patients With Newly Diagnosed Colorectal Cancer (CRC) or Pancreatic Ductal Adenocarcinoma (PDAC) Undergoing ChemotherapyThis is a randomized, double-blind, placebo-controlled basket trial evaluating mifomelatide (TCMCB07) administered daily by subcutaneous (SC) injection in up to 120 patients.NCT06937177·Tucson, Arizona and 25 others

TerminatedCombination Chemotherapy Plus Trastuzumab in Treating Patients With Advanced, Recurrent, or Metastatic Colorectal CancerRATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.NCT00006015·Birmingham, Alabama and 46 others

Active not recruitingA Study of Novel Study Interventions and Combinations in Participants With Colorectal CancerThe main purpose of this study is to evaluate the safety and efficacy of novel study interventions and combinations in participants with Colorectal Cancer (CRC).NCT06792695·Scottsdale, Arizona and 55 others

CompletedStudy of Vitamin D in Untreated Metastatic Colorectal CancerThis is a prospective, randomized, double-blind phase II trial to evaluate the efficacy and safety of two doses of vitamin D supplementation in combination with standard…NCT01516216·Boise, Idaho and 17 others

CompletedSample Collection Study to Evaluate DNA Markers in Subjects With Inflammatory Bowel Disease (IBD)The primary objective of this study is to gather stool samples from subjects with inflammatory bowel disease (IBD) to be added to a test set of stool samples that will be utilized…NCT02503696·Dothan, Alabama and 28 others

RecruitingA Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid TumorsThis is a Phase 1/2 open-label, multi-center, multi-national study with an initial dose escalation part to determine the recommended Phase II dose (RP2D) of MCLA-158 single agent…NCT03526835·La Jolla, California and 53 others

CompletedStudy of Gamma Interfereon in Metastatic Colorectal CarcinomaThe purpose of this study is to evalute the response and toxicity of metastatic colorectal cancer patients to the regimen of gamma interferon added to bolus and infusional…NCT00786643·Memphis, Tennessee

CompletedStudy of XL281 in Adults With Solid TumorsThe purpose of this study is to determine the safest dose of the multiple Raf kinase inhibitor (including c-Raf, B-Raf, and the activated mutant B-RafV600E) XL281, how often it…NCT00451880·Scottsdale, Arizona and 5 others

Active not recruitingSafety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLCThis is a First-in-Human Phase IA/IB/II open label dose escalation study of intravenous (IV) administration of ONC-392, a humanized anti-CTLA4 IgG1 monoclonal antibody, as single…NCT04140526·Springdale, Arkansas and 36 others

Active not recruitingStudy to Determine the Safety, Tolerability, Pharmacokinetics and Recommended Phase 2 Dose (RP2D) of Livmoniplimab (ABBV-151) as a Single Agent and in Combination With Budigalimab (ABBV-181) in Participants With Locally Advanced or Metastatic Solid TumorsThe study will determine the recommended Phase 2 dose (RP2D) of livmoniplimab (ABBV-151) administered as monotherapy and in combination with budigalimab (ABBV-181) as well as to…NCT03821935·Springdale, Arkansas and 63 others

CompletedSotorasib and Panitumumab Versus Investigator's Choice for Participants With Kirsten Rat Sarcoma (KRAS) p.G12C MutationThe aim of the study is to compare progression-free survival (PFS) in previously treated participants with Kirsten rat sarcoma (KRAS) p.G12C mutated colorectal cancer (CRC)…NCT05198934·Birmingham, Alabama and 104 others

CompletedCOM701 (an Inhibitor of PVRIG) in Subjects With Advanced Solid Tumors.This is a Phase 1 open label sequential dose escalation and cohort expansion study evaluating the safety, tolerability and preliminary clinical activity of COM701 as monotherapy…NCT03667716·Los Angeles, California and 10 others

CompletedA Study of Brontictuzumab With Chemotherapy for Subjects With Previously Treated Metastatic Colorectal CancerA Phase 1b Dose Escalation Study of the Safety and Pharmacodynamics of Brontictuzumab in Combination with Chemotherapy for Subjects with Previously Treated Metastatic Colorectal…NCT03031691·Denver, Colorado and 4 others

CompletedBevacizumab and Oxaliplatin Combined With Irinotecan or Leucovorin and Fluorouracil in Treating Patients With Metastatic or Recurrent Colorectal CancerRATIONALE: Drugs used in chemotherapy, such as oxaliplatin, irinotecan, leucovorin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing…NCT00098787·Greenbrae, California and 109 others

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Other Conditions in Tennessee

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