Combination Chemotherapy Plus Trastuzumab in Treating Patients With Advanced, Recurrent, or Metastatic Colorectal Cancer

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed advanced, recurrent, or metastatic colorectal adenocarcinoma
• Resected CNS metastases stable greater than 1 month after completion of radiotherapy for CNS metastases eligible
• * No existing CNS metastases allowed
• Measurable disease
• * At least 1 dimension as at least 20 mm with conventional techniques OR
• * At least 10 mm with spiral CT scan
• * No truly nonmeasurable lesions:
• * Bone lesions
• * Leptomeningeal disease
• * Lymphangitis cutis/pulmonis
• * Abdominal masses not confirmed and followed by imaging techniques
• * Cystic lesions
• Must have progressed on at least 1 prior, but no more than 2 prior, fluorouracil and/or irinotecan containing treatment regimens for metastatic colorectal cancer
• Must have documented HER-2/neu overexpression by immunohistochemistry staining
• * Staining score at least 2+
• PATIENT CHARACTERISTICS:
• Age:
• 18 and over
• Performance status:
• ECOG 0-2
• Life expectancy:
• Not specified
• Hematopoietic:
• Granulocyte count at least 1,500/mm3
• Platelet count at least 100,000/mm3
• Hepatic:
• Bilirubin no greater than 2.0 mg/dL
• AST no greater than 2.5 times upper limit of normal
• Renal:
• Creatinine normal OR
• Creatinine clearance at least 60 mL/min
• Cardiovascular:
• No history of cardiac ischemia or congestive heart failure
• LVEF at least 50% by ECG or MUGA
• Other:
• Not pregnant or nursing
• Fertile patients must use effective contraception
• No concurrent second malignancy except nonmelanoma skin cancers or carcinoma in situ of the cervix unless completed therapy and considered to be at less than 30% risk of relapse
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• Not specified
• Chemotherapy:
• See Disease Characteristics
• No prior platinum containing chemotherapy
• At least 3 weeks since prior chemotherapy and recovered
• No other concurrent chemotherapy
• Endocrine therapy:
• Not specified
• Radiotherapy:
• At least 3 weeks since prior radiotherapy and recovered
• Surgery:
• Not specified