A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

Exclusion Criteria

• •Central nervous system metastases or spinal cord compression
• •Known history of severe allergy to any monoclonal antibody or study intervention.
• •Any unresolved toxicity CTCAE Grade ≥ 2 from a previous anticancer therapy.
• •History of another primary malignancy.
• •Potentially resectable disease with multidisciplinary plan for radical surgery.
• •Active or prior documented autoimmune or inflammatory disorders or cardiac conditions.
• •Participants with a prior history of hypertensive crisis or hypertensive encephalopathy or bleeding risks.
• •Deep venous thrombosis, pulmonary embolism, arterial thrombosis, transient ischemic attack or cerebrovascular accident.
• •History of abdominal or tracheoesophageal fistula, GI perforation and/or fistulae, or intraabdominal abscess within 6 months prior to randomization.
• •Prior exposure to immune mediated therapy.