Clinical Trials in Pittsburgh

Showing 1761-1780 of 10,050 trials

Study of the Immune Response of MUC1 (Mucin1) Peptide Vaccine for Non-small Cell Lung Cancer

NCT01720836

All subjects will receive the vaccine subcutaneously every 3 weeks x 3 with optional yearly booster vaccines up to and including 5 years post last vaccine for those patients who are confirmed responders to the vaccine . The rationale for using Poly-ICLC as an adjuvant are two ongoing trials at University of Pittsburgh Cancer Institute (UPCI) of the MUC1 100mer peptide vaccine - one as a therapeutic vaccine in subjects with metastatic castrate resistant prostate cancer and the other in subjects with advanced colonic adenomas at risk for developing colon cancer. The same formulation, MUC1 100mer peptide admixed with Poly-ICLC, is used in both trials. There has been no toxicity observed and the vaccine is highly immunogenic in early disease. In the proposed NSCLC trial the anti-MUC1 immune response will be thoroughly characterized.

Non-small Cell Lung Cancer (NSCLC)

Olivera Finn30 participantsStarted Nov 2012

Pittsburgh, Pennsylvania, United States

COMPLETEDPhase 3< 1 mile

Open-label Long-term Study of Adjunctive Brivaracetam in Pediatric Subjects With Epilepsy

NCT01364597

This study will evaluate the safety and tolerability of brivaracetam in pediatric subjects with epilepsy.

Epilepsy

UCB Pharma SA257 participantsStarted Aug 2011

Los Angeles, California, United States • Gulf Breeze, Florida, United States • Wellington, Florida, United States +53 more locations

Study of the Immune Response of MUC1 (Mucin1) Peptide Vaccine for Non-small Cell Lung Cancer

Open-label Long-term Study of Adjunctive Brivaracetam in Pediatric Subjects With Epilepsy

Find Trials by Condition in Pittsburgh

GRAVITAS-309: Itacitinib and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

Testing the Addition of the Immune Therapy Drugs, Tocilizumab and Atezolizumab, to Radiation Therapy for Recurrent Glioblastoma

To Evaluate Efficacy and Safety of Serplulimab + Chemotherapy (Carboplatin- Etoposide) in US Patients With ES-SCLC

Personalized Therapy Study - HFRS (TriageHF) Post Approval Study

Medtronic Transcatheter Aortic Valve Replacement (TAVR) Low Risk Bicuspid Study

A Study to Learn How Well the Study Treatment Finerenone Works and How Safe it is in People With Long-term Decrease in the Kidneys' Ability to Work Properly (Chronic Kidney Disease) Together With Type 1 Diabetes

Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Postoperative Pain After Mastectomy

Trial of Indication-Based Transfusion of Red Blood Cells in ECMO

Immunotherapy for Third Line Metastatic Colorectal Cancer

Study of RP-3500, Camonsertib, in Advanced Solid Tumors

Nonhealing Diabetic Foot Ulcers Treated With Standard of Care (SOC) Alone or Standard of Care and Amnion-Intermediate-Chorion (AIC)

Study of Fordadistrogene Movaparvovec in Early Stage Duchenne Muscular Dystrophy

PMT for MDRO Decolonization

Hearing Impairment, Strategies and Outcomes in VA Emergency Departments

A Study of Zolbetuximab (IMAB362) in Adults With Gastric Cancer

Combined AlloStim+Anti-PD-L1 in 4L MSS Metastatic Colorectal Cancer

TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

Study of Diagnostic Performance of [18F]CTT1057 in BCR