* Somatostatin analogues: no washout period required
Karnofsky performance status ≥ 60.
Concomitant treatment with somatostatin analogues unless concomitant treatment was discontinued 28 days before first pasireotide LAR injection is administrated.
Concomitant treatment with growth hormone receptor (GHR)-antagonists or dopamine agonists unless concomitant treatment was discontinued and the washout period was completed before the screening assessments are performed.
Patients with compression of the optic chiasm causing any visual field defect for whom surgical intervention is indicated.
Patients who require a surgical intervention for relief of any sign or symptom associated with tumor compression.
Patients who have undergone major surgery/surgical therapy for any cause within 4 weeks of screening.
Patients who have received radiotherapy of the pituitary within 4 weeks prior to screening or have not recovered from side effects of radiotherapy.
Patients who have a history of hypothyroidism and who are not adequately treated with stable doses of thyroid hormone replacement therapy.
Patients with active malignant disease within the last five years (with the exception of basal cell carcinoma or carcinoma in situ of the cervix).
Diabetic patients whose blood glucose is poorly controlled.
