Evaluation of Neutrophil Gelatinase-associated Lipocalin (NGAL) in Early and Evolving Acute Kidney Injury

Exclusion Criteria

• •Age \< 18 years
• •Inability to obtain Informed Consent from patient or representative
• •Prisoners or other institutionalized or vulnerable individuals
• •Participation in an interventional clinical study within the previous 30 days
• •History of previous renal transplantation
• •Stage 5 chronic kidney disease (estimated GRF\<15 mL/min/1.73m2) (See Appendix C)
• •Known or suspected ongoing pre-operative acute renal failure due to any cause, including pre-renal, intrinsic renal or post-renal (obstructive) etiologies (as evidenced by increasing serum creatinines or oliguria pre-operatively)
• •Already receiving dialysis, in imminent need of dialysis or considered highly likely to need dialysis in the immediate post-operative period for fluid management
• •Any known or suspected renal ischemic insult(such as cardiac arrest)or nephrotoxic insult(other than intravascular contrast procedure) during the 48 hours prior to surgery
• •Known or suspected infection with human immunodeficiency virus (HIV), hepatitis C virus (HCV)infection, hepatitis B virus (HBV) infection or other infectious hepatitis
• •Pre-operative hematocrit \<25%, recent blood transfusions have been administered to maintain hematocrit \>25% or any other contraindication to obtaining the study-specified blood samples
• •Undergoing cardiac transplantation