Clinical Trials in Pittsburgh

Showing 4661-4680 of 21,047 trials

Lithium As a Treatment to Prevent Impairment of Cognition in Elders

NCT03185208

Alzheimer's disease (AD) is the most common cause of dementia in adults 65 years and older. AD leads to a complete loss of memory and independent function, and presently there is no cure. Many studies suggest that lithium treatment may delay dementia onset or slow its progression. However, more research is needed to understand the extent of its anti-dementia properties if it will be deployed broadly in the general population. This study will examine whether lithium has anti-dementia properties in older adults who have mild cognitive impairment and are at risk of becoming demented.

Mild Cognitive Impairment

Ariel Gildengers, MD83 participantsStarted Feb 2018

Pittsburgh, Pennsylvania, United States

COMPLETEDPhase 3< 1 mile

A Study Comparing ATB200/AT2221 With Alglucosidase Alfa/Placebo in Adult Subjects With Late-onset Pompe Disease

NCT03729362

This is a phase 3 double-blind randomized study to study the efficacy and safety of intravenous ATB200 Co-administered with oral AT2221 in adult subjects with Late Onset Pompe Disease compared with Alglucosidase Alfa/placebo.

Pompe Disease (Late-onset)

Amicus Therapeutics125 participantsStarted Dec 2018

Phoenix, Arizona, United States • Little Rock, Arkansas, United States • Irvine, California, United States +70 more locations

Lithium As a Treatment to Prevent Impairment of Cognition in Elders

A Study Comparing ATB200/AT2221 With Alglucosidase Alfa/Placebo in Adult Subjects With Late-onset Pompe Disease

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Development and Testing of imHere4U: A Digital Suicide Prevention Intervention for Cyberbullied Adolescents

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

A Study Comparing Upadacitinib (ABT-494) to Placebo in Participants With Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Biologic Disease Modifying Anti-Rheumatic Drug

Screening Contrast-Enhanced Mammography as an Alternative to MRI

Study of Cabozantinib in Combination With Nivolumab and Ipilimumab in Patients With Previously Untreated Advanced or Metastatic Renal Cell Carcinoma

A Study of mRNA-1010 Compared With a Licensed Influenza Vaccine in Adults ≥50 Years of Age

Study of Lademirsen (SAR339375) in Patients With Alport Syndrome

A First-in-Human Dose Escalation and Expansion Study to Evaluate Intratumoral Administration of SAR441000 as Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors

A Study to Evaluate Efficacy and Safety of Deucravacitinib in Participants With Active Discoid and/or Subacute Cutaneous Lupus Erythematosus (DLE/SCLE)

A Study Comparing Venetoclax and Azacitidine Plus Cusatuzumab to Venetoclax and Azacitidine in Newly Diagnosed AML Ineligible for Intensive Therapy

Single Ascending Dose Study of SAR439459 in Adults With Osteogenesis Imperfecta (OI)

Study of mRNA Vaccine Formulation Against COVID-19 in Healthy Adults 18 Years of Age and Older

A Study of an Investigational Flu Seasonal/SARS-CoV-2 Combination Vaccine in Adults

A Study of Belrestotug Plus Dostarlimab Compared With Placebo Plus Pembrolizumab in Previously Untreated Participants With Programmed Death Ligand 1 (PD-L1) High Non-small-cell Lung Cancer (NSCLC)

Effectiveness of Remote Foot Temperature Monitoring

Use of Dalfampridine in Primary Lateral Sclerosis

A Phase 2 Study of YA-101 in Patients With Multiple System Atrophy

A Study of Subcutaneous (SC) Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) vs Intravenous Pembrolizumab in Adult Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) (MK-3475A-D77)