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Periprosthetic Joint Infection Bubble Study

NCT07599865·3 sites·ClinicalTrials.gov

What this study is about

Take this into the appointment.

Saves the questions and what to expect into your notes, next to the visit they belong to.

Keep this study

Lead

Thomas Jefferson University

With

National Institute of Allergy and Infectious Diseases (NIAID)

Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

You may be eligible if

Be at least 18 years of age
Be medically stable
If female of child-bearing potential, must have a negative pregnancy test
Be conscious and able to comply with study procedures
Have read and signed the IRB-approved Informed Consent form for participating in the study
For Cohort 1, be scheduled for one- or two-stage exchange arthroplasty revision surgery for PJI of the knee
For Cohort 2, be scheduled for DAIR revision surgery for PJI of the knee

You may not be if

Females who are pregnant or nursing
Patients currently on chemotherapy requiring systemic infusion treatment
Patients who are medically unstable, patients who are seriously or terminally ill, and patients whose clinical course is unpredictable
Patients with a history of anaphylactic allergy to perflutren or any other components of Definity
Patients with a history of failed one- or two-stage revision for infection
Patients for which placement of a surgical drain is contraindicated
Patients in protected classes (e.g., prisoners)

The record

StatusRecruiting

PhasePhase 2

Taking part100

StartedAug 2026

UpdatedSep 23, 2026

Conditions

Periprosthetic Joint Infection (PJI)

Where3

Thomas Jefferson University/Rothman Institute
Philadelphia, Pennsylvania, United States
University of Pittsburgh Medical Center (UPMC)
Pittsburgh, Pennsylvania, United States
UT Southwestern Medical Center
Dallas, Texas, United States

Clareo Health | Periprosthetic Joint Infection Bubble Study