Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

Diabetes
Painful Diabetic Neuropathy (confirmed at screening visit)
Willing to accept random treatment assignment to any of the proposed interventions

Pregnancy or plans to become pregnant during the study
History of neuropathy from causes other than diabetes as determined through medical and family history, physical and neurologic examinations
HbA1c \>10%
Participation in an experimental medication trial within 3 months of starting the study
Undergoing therapy for malignant disease other than basal-cell or squamous-cell skin cancer
Medical or psychiatric reason for not being a study candidate according to the site PI's discretion
Contraindications preventing trialing two interventions within any of the 3 modalities
Cirrhosis of the liver

Modality Choice Before and After Failure for the Treatment of Painful Diabetic Neuropathy