Clinical Trials in Philadelphia

Showing 18301-18320 of 20,904 trials

Healthy Growth Abbreviated Pilot Study

NCT01977105

This is a single-group feasibility pilot trial of a peer-based, social media intervention to prevent obesity in infants.

Childhood Obesity

Children's Hospital of Philadelphia9 participantsStarted Sep 2013

Philadelphia, Pennsylvania, United States

TERMINATEDPhase 1< 1 mile

Effects of Dual Cyclooxygenase-2 and Carbonic Anhydrase Inhibition

NCT00780325

Cyclooxygenase-2 (COX-2) inhibitors have become a common analgesic treatment option for patients with arthritis. However, long-term treatment has been associated with increased cardiovascular risk. With the past withdrawals and rejections of approval for COX-2 inhibitors the treatment options are now very limited. This translates for example to about 10 million osteoarthritis patients in the US who cannot receive COX-2 inhibitors because of concomitant hypertension. And this exemplifies the unmet medical need to develop and offer safe treatment options for this particular patient population. This trial investigates pharmacodynamic aspects of CG100649 which is being developed as a novel COX-2 inhibitor. Preclinical data show a dual mechanism of action, which consists of the inhibition of the two enzymes COX-2 and carbonic anhydrase-I/-II (CA-I/II) and through which the cardiovascular risk of COX-2 inhibition might be attenuated.

Healthy Volunteers

University of Pennsylvania26 participantsStarted Oct 2008

Philadelphia, Pennsylvania, United States

Healthy Growth Abbreviated Pilot Study

Effects of Dual Cyclooxygenase-2 and Carbonic Anhydrase Inhibition

Find Trials by Condition in Philadelphia

A Weight Loss Trial for Emotional Eating

Efficacy and Safety Study of GS-9450 Treatment for 6 Months in Patients With Chronic Hepatitis C Virus Infection

Study of Cicletanine for Pulmonary Arterial Hypertension (PAH)

Efficacy and Safety Study of BERIPLEX® P/N (Kcentra) Compared With Plasma in Patients With Acute Major Bleeding Caused by Anticoagulant Therapy

Care Managers for Perinatal Depression (CMPD)

Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma

A Multiple Dose Study Of PD-0360324 In Patients With Active Cutaneous Lupus Erythematosus

Results of Tc99m-Maraciclatide Scintigraphy in Subjects With Diabetes Mellitus and Heart Failure With Preserved Left Ventricular Ejection Fraction

Safety Study Providing 12 Months Follow-up From First Exposure to HP802-247 in Subjects With Venous Leg Ulcer

Radiation Therapy With or Without Cetuximab in Treating Patients With Stage III or Stage IV Cancer of the Oropharynx, Hypopharynx, or Larynx

Extension Study of Long-term Safety and Efficacy of Myozyme in Patients With Pompe Disease Who Were Previously Enrolled in Genzyme Sponsored Enzyme Replacement Therapy (ERT) Studies

A Study of the Safety and Pharmacokinetics of rhGAA in Siblings With Glycogen Storage Disease Type II

Side Effects and Adherence Associated With Doxycycline Use Following Medical Abortion

Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP)

Phase 2 Chronic Low Back Pain Study

Efficacy and Safety of Linagliptin in Elderly Patients With Type 2 Diabetes

Extension Study of Patients With Infantile-Onset Pompe Disease Who Were Previously Enrolled in Protocol AGLU01602

rhGAA in Patients With Infantile-onset Glycogen Storage Disease-II (Pompe Disease)