Effects of Dual Cyclooxygenase-2 and Carbonic Anhydrase Inhibition

Part 1 and 2 (staged analysis): Single dose of study drugs \[celecoxib, placebo\] followed by 3 days of blood draws as Period I; then after a wash-out phase, single dose of study drugs \[CG100649 2mg and 8mg, celecoxib 200mg, placebo\], followed by blood draws on 6 days and bi-weekly urine collections for 8 weeks. Part 3: Five-way cross-over of single doses of study drugs with a CG100649 single dose level as determined by part 1 and 2, celecoxib 200mg, naproxen 500mg, acetazolamide 250mg and placebo.