Clinical Trials in Philadelphia

Showing 6341-6360 of 20,904 trials

A Socio-ecological Approach for Improving Self-management in Adolescents With SCD

NCT06290401

The goal of this clinical trial is to evaluate the impact of SCThrive (a behavioral self-management intervention) on patient activation, self-management behaviors, daily functioning, and emergency room visits in 260 adolescents and young adults with sickle cell disease (SCD) ages 13-21 receiving care at 1 of 4 pediatric SCD clinics. The main question\[s\]it aims to answer are: * Does SCThrive improve patient activation? * Does SCThrive improve self-management behaviors, daily functioning, and decrease emergency room visits? * Are any improvements maintained 3 months after treatment? Participants will complete self-management related surveys before, after, and 3 months following their participation in an 8- week, virtual group intervention with an accompanying mobile app (SCThrive). Researchers will compare outcomes for participants who receive SCThrive and participants who receive uniform standard care (SCHealthED which = standard of care plus SCD educational text messages) to see if there are differences in patient activation, self-management behaviors, daily functioning, and emergency room visits.

Anemia, Sickle Cell

Children's Hospital Medical Center, Cincinnati310 participantsStarted Feb 2025

Wilmington, Delaware, United States • Atlanta, Georgia, United States • Cincinnati, Ohio, United States +1 more locations

COMPLETEDPhase 2< 1 mile

Phase 2 Trial to Evaluate Belzupacap Sarotalocan (AU-011) Via Suprachoroidal Administration in Subjects With Primary Indeterminate Lesions and Small Choroidal Melanoma

NCT04417530

The primary objective is to determine the safety, tolerability, and preliminary efficacy of belzupacap sarotalocan for the treatment of primary indeterminate lesions and small choroidal melanoma (IL/CM).

Uveal MelanomaOcular MelanomaChoroidal Melanoma

Aura Biosciences22 participantsStarted Aug 2020

Tucson, Arizona, United States • Los Angeles, California, United States • Palo Alto, California, United States +19 more locations

A Socio-ecological Approach for Improving Self-management in Adolescents With SCD

Phase 2 Trial to Evaluate Belzupacap Sarotalocan (AU-011) Via Suprachoroidal Administration in Subjects With Primary Indeterminate Lesions and Small Choroidal Melanoma

Find Trials by Condition in Philadelphia

A Double-blind Study to Investigate Efficacy and Safety of Buntanetap Compared With Placebo in Participants With Early PD

PROACTIVE-HF IDE Trial Heart Failure NYHA Class III

Prokinetics and Body Surface Gastric Mapping in Dyspeptic Patients: Baseline and Treatment Effects

Do Patients With Chronic Daily Headache Have Continuous Headache or Moments of Headache Relief?

NAP in Combination With Docetaxel Following Obinutuzumab Pretreatment in Subjects With Checkpoint Inhibitor Pretreated Advanced or Metastatic NSCLC

XB2001 in Combination With ONIVYDE + 5-FU/LV (+Folinic Acid) in Advanced Pancreatic Cancer

Efficacy of Albumin Dialysis to Treat Patients With Hepatic Encephalopathy Using The Molecular Adsorbent Recirculating System (MARS)

EPI-7386 in Combination with Enzalutamide Compared with Enzalutamide Alone in Subjects with MCRPC

Oral EPI-7386 in Patients with Castration-Resistant Prostate Cancer

Maintenance NeuroStar Transcranial Magnetic Stimulation (TMS) in Patients With Major Depressive Disorder

Cisplatin and Gemcitabine Hydrochloride With or Without Berzosertib in Treating Patients With Metastatic Urothelial Cancer

Study to Evaluate the OrthoCor Active System for Pain Relief

Lipoic Acid for Progressive Multiple Sclerosis (MS)

Study to Assess the Safety and Immunogenicity of GSK Meningococcal Group B Vaccine When Administered Concomitantly With GSK Meningococcal MenACWY Conjugate Vaccine in Healthy Subjects of 16-18 Years of Age

Cardiovascular Risk Screening and Risk Reduction in Women Vets

Safety and Efficacy of Oral GKT137831 in Patient With Type 2 Diabetes and Albuminuria

TAEK-VAC-HerBy Vaccine for Brachyury and HER2 Expressing Cancer

An Observational Study to Assess Change in Disease Activity and Adverse Events of Upadacitinib in Adult Participants With Moderate to Severe Ulcerative Colitis (UC) in Real-World Practice