Safety and Efficacy of Oral GKT137831 in Patient With Type 2 Diabetes and Albuminuria

Exclusion Criteria

• •History of type 1 diabetes
• •Any other non-diabetic kidney disease(s) except for hypertensive nephropathy which is acceptable.
• •Diagnostic or interventional procedure requiring a contrast agent within 4 weeks of the first screening visit (Visit 1) or planned during the study.
• •History of renal transplant or planned renal transplant during the study.
• •A history of acute renal dialysis or acute kidney injury (defined according to the Kidney Disease: Improving Global Outcomes \[KDIGO\] definition) within 12 weeks of the first screening visit (Visit 1)
• •HbA1c level \>11% (97 mmol/mol).
• •History of hypothyroidism requiring hormone replacement therapy.
• •History of active cardiovascular disease
• •A personal or family history of long QT syndrome.
• •Administration of any investigational product within 30 days or within 5 half-lives of the investigational agent